Abstract Purpose: To measure the tissue sulfomucin and sialomucin content of the colon mucosa without fecal flow, subjected to intervention with curcumin, and the influence of the concentration used and the intervention time. Methods: Thirty-six rats were subjected to proximal right colostomy and dis...
Colon/química,
Colon/efectos de los fármacos,
Mucosa Intestinal/química,
Mucosa Intestinal/efectos de los fármacos,
Mucinas/análisis,
Extractos Vegetales/administración & dosificación,
Colitis/tratamiento farmacológico,
Colitis/patología,
Colon/patología,
Colostomía,
Curcuma,
Enema/métodos,
Heces,
Tránsito Gastrointestinal/efectos de los fármacos,
Procesamiento de Imagen Asistido por Computador,
Mucosa Intestinal/patología,
Mucinas/efectos de los fármacos,
Aceites de Plantas/administración & dosificación,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sialomucinas/efectos de los fármacos,
Factores de Tiempo
Abstract Purpose: To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and...
Claudina-3/análisis,
Colon/química,
Curcuma/química,
Enema/métodos,
Mucosa Intestinal/química,
Ocludina/análisis,
Aceites de Plantas/farmacología,
Colon/efectos de los fármacos,
Colon/patología,
Colostomía,
Heces,
Inmunohistoquímica,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Ratas Wistar
Abstract The aim of the present study was to evaluate the effect of systemic administration of probiotics (PROB) on the progression of experimentally induced oral and intestinal mucositis in rats immunosuppressed by chemotherapy (5-fluorouracil: 5-FU). Twenty-four rats were divided into the following gro...
Biopsia,
Enteritis/inducido químicamente,
Enteritis/patología,
Enteritis/terapia,
Inmunocompetencia,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Intestino Delgado/efectos de los fármacos,
Intestino Delgado/patología,
Mucosa Bucal/efectos de los fármacos,
Mucosa Bucal/patología,
Probióticos/uso terapéutico,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Estomatitis/inmunología,
Estomatitis/patología,
Estomatitis/terapia,
Factores de Tiempo,
Resultado del Tratamiento
ABSTRACT PURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-...
Carnitina/farmacología,
Colitis/prevención & control,
Colitis,
Mucosa Intestinal/efectos de los fármacos,
Traumatismos Experimentales por Radiación/tratamiento farmacológico,
Protectores contra Radiación/farmacología,
Colitis/inducido químicamente,
Colitis/patología,
Modelos Animales de Enfermedad,
Mucosa Intestinal/patología,
Protección Radiológica,
Distribución Aleatoria
ABSTRACT Objective: to evaluate the effect of L-lysine in the bladder and intestinal epithelia in rats submitted to vesicosigmoidostomy. Methods: we divided forty Wistar rats into four groups: group I - control group (Sham); group II - submitted to vesicosigmoidostomy and treated with L-lysine 150mg/k...
ABSTRACT Background Nonsteroidal anti-inflammatory drugs induces gastric mucosal lesions because of its acidic properties. Ranitidine, an H2 receptor antagonist, has proved beneficial in patients with gastric ulcers. Objective The present study was performed to assess the effect of administering raniti...
Antiinflamatorios no Esteroideos/farmacología,
Diclofenaco/farmacología,
Mucosa Gástrica/efectos de los fármacos,
Mucosa Gástrica/patología,
Antagonistas de los Receptores H2 de la Histamina/farmacología,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Riñón/efectos de los fármacos,
Riñón/patología,
Ranitidina/farmacología,
Úlcera Gástrica/inducido químicamente,
Úlcera Gástrica/prevención & control,
Sulfonamidas/farmacología,
Ratas Wistar
Ulcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment...
Foi realizado um estudo aberto, näo comparativo, com o Misoprostol, prostaglandina sintética no tipo E1, na terapêutica de 30 pacientes portadores de osteoartrose em uso de Naproxen e que, concomitantemente, exibiram manifestaçöes clínicas relativas ao trato gastrintestinal superior. Esses paciente...
