Results: 24

Quantification of pro-inflammatory cytokines and osteoclastogenesis markers in successful and failed orthodontic mini-implants

J. appl. oral sci; 27 (), 2019
Abstract Objectives: Miniscrew has been frequently used, considering that anchorage control is a critical point in orthodontic treatment, and its failure, the main adverse problem. Using two groups of stable (successful) and unstable (failed) mini-implants, this in vivo study aimed to quantify proinflam...

Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TGF-β and TNF-α: follow-up over 5 years

J. appl. oral sci; 27 (), 2019
Abstract Objective The aim of this study was to evaluate the levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TG-β and TNF-α in individuals with diagnosis of peri-implant mucositis in the absence or presence of periodontal and peri-implant maintenance therapy (TMPP) over 5 y...

Avaliação do reparo ósseo na interface osso/implante em ratas com deficiência de estrógeno tratadas com OPG-Fc humano ou ranelato de estrôncio: análise histométrica, imunoistoquímica, biomecânica, por microtomografia computadorizada e microscopia confocal

Objetivo: Avaliar o reparo ósseo periimplantar em ratas submetidas à ovariectomia e tratadas com Ranelato de Estrôncio (625mg/kg/dia) ou OPG-Fc (10mg/Kg/2 vezes por semana). Material e Método: Sessenta e quatro ratas, com peso aproximado de 300 gramas, divididas em 4 grupos experimentais conforme tra...

Immunohistochemical expression of RANKL in oral giant cell lesions is predictive of aggressiveness

Abstract The aim of this study was to evaluate the immunohistochemical expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and of osteoprotegerin (OPG), important proteins correlated with osteoclastogenesis, in central giant cell lesions (CGCL) and peripheral giant cell lesions (PGC...

Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice

J. appl. oral sci; 26 (), 2018
Abstract Objective To evaluate and correlate, in the same research, the mRNA expression and the staining of RANK, RANKL, OPG, TLR2 and MyD88 by immunohistochemistry in the apical periodontitis (AP) progression in mice. Material and Methods AP was induced in the lower first molars of thirty-five C57BL...

Alveolar bone healing in rats: micro-CT, immunohistochemical and molecular analysis

J. appl. oral sci; 26 (), 2018
Abstract Alveolar bone healing after upper incisor extraction in rats is a classical model of preclinical studies. The underlying morphometric, cellular and molecular mechanism, however, remains imprecise in a unique study. Objectives The aim of this study was therefore to characterize the alveolar bon...

Evolution of Periodontal Disease: Immune Response and RANK/RANKL/OPG System

Braz. dent. j; 28 (6), 2017
Abstract The aim of this study was to evaluate markers of bone loss and immune response present in evolution of periodontal disease. One hundred and two Wistar rats were divided into three animals groups: PD0, without ligation and PD15 days and PD60 days, submitted to ligation placement with a sterile 3-...

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Acta cir. bras; 32 (6), 2017
Abstract Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model. Methods: Thirty-six 6-week-old Male SD rats were randoml...

Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment

Clinics; 72 (4), 2017
OBJECTIVES: The present study was designed to evaluate the bone phenotypes and mechanisms involved in bone disorders associated with hepatic osteodystrophy. Hepatocellular disease was induced by carbon tetrachloride (CCl4). In addition, the effects of disodium pamidronate on bone tissue were evaluated. ...

Anquilose da articulação temporomandibular na infância: análise da expressão gênica da osteoprotegerina e do ligante do fator ativador do receptor nuclear kappa-b

A anquilose da articulação temporomandibular (AATM) apesar de rara, é uma doença grave e de difícil tratamento, que restringe os movimentos articulares acarretando ao paciente problemas estéticos, nutricionais, psicológicos e sociais. A formação do bloco ósseo anquilótico determina a gravidade...