Objetivo: estimar o impacto orçamentário incremental da terapia-alvo para tratamento de primeira linha do melanoma avançado não cirúrgico e metastático, em comparação à dacarbazina. Métodos: análise de impacto orçamentário na perspectiva do Sistema Único de Saúde (SUS) do Brasil; a partir...
Melanoma/epidemiología,
Melanoma/tratamiento farmacológico,
Terapia Molecular Dirigida/métodos,
Terapia Molecular Dirigida/tendencias,
Dacarbazina/uso terapéutico,
Dacarbazina/administración & dosificación,
Neoplasias Cutáneas/tratamiento farmacológico,
Metástasis de la Neoplasia/tratamiento farmacológico,
Costos y Análisis de Costo/tendencias,
Costos de la Atención en Salud/tendencias,
Antineoplásicos/economía,
Sistema Único de Salud,
Salud Pública/tendencias
Abstract Introduction: In last few years, emphasis was placed in goal-directed therapy in order to optimize patient's hemodynamic status and improve their prognosis. Parameters based on the interaction between heart and lungs have been questioned in situations like low tidal volume and open chest surger...
ABSTRACT We conducted a systematic review and meta-analysis of the literature on the efficacy of the targeted therapies in the treatment of advanced RCC and, via an indirect comparison, to provide an optimal treatment among these agents. A systematic search of Medline, Scopus, Cochrane Library and Clinic...
The most successful treatment for cancer involves identifying druggable, biological markers for targeted therapy. In the clinical setting, surgical removal of tumors is the only procedure for identifying such targetable molecules. Shed from tumor cells, these markers are also present in circulating blood...
Luna, R C P;
de Oliveira, Y;
Lisboa, J V C;
Chaves, T R;
de Araújo, T A M;
de Sousa, E E;
Miranda Neto, M;
Pirola, L;
Braga, V A;
de Brito Alves, J L.
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart fail...
Metilación de ADN/genética,
Regulación hacia Abajo/genética,
Epigénesis Genética/genética,
Código de Histonas/genética,
Hipertensión Pulmonar/genética,
Hipertensión Pulmonar/fisiopatología,
Hipertensión Pulmonar/terapia,
Terapia Molecular Dirigida,
Arteria Pulmonar/patología,
ARN no Traducido/genética,
Ubiquitinación/genética,
Regulación hacia Arriba/genética
Las Rho GTPasas son una familia de proteínas que actúan como interruptores moleculares en diversas vías de señalización coordinando la regulación de distintos procesos celulares. La desregulación de dichas proteínas se vincula con transformación maligna y progresión tumoral en distintos tipos d...
ABSTRACT Objectives To further elucidate which patients with metastatic renal cell carcinoma (mRCC) may benefit from cytoreductive nephrectomy (CN) before targeted therapy (TT), and to assess the overall survival of patients undergoing CN and TT versus TT alone. Materials and Methods We identified 88...
Procedimientos Quirúrgicos de Citorreducción,
Terapia Combinada,
Carcinoma de Células Renales/terapia,
Carcinoma de Células Renales/secundario,
Neoplasias Renales/terapia,
Estimación de Kaplan-Meier,
Persona de Mediana Edad,
Terapia Molecular Dirigida,
Nefrectomía/métodos,
Cuidados Preoperatorios,
Estudios Retrospectivos,
Factores de Riesgo
Diante da necessidade de uma metodologia para buscar e avaliar a relevância do desenvolvimento de inibidores para enzimas específicas em um organismo patógeno que pudesse ser aplicada em sistemas hospedeiro-parasito em geral foram utilizados dois modelos; um envolvendo um vertebrado, Homo sapiens, e u...
ABSTRACT Aptamers are short single-stranded RNA or DNA oligonucleotides that are capable of binding various biological targets with high affinity and specificity. Their identification initially relies on a molecular process named SELEX (Systematic Evolution of Ligands by EXponential enrichment) that has ...
Cutaneous melanoma is a highly aggressive tumor developing from melanocytes, its incidence is increasing, and prognosis in advanced stages is daunting. New therapies have been approved during the recent years with unprecedented results, including inhibitors of MAPK/ERK pathway and immune checkpoint block...
Antineoplásicos/uso terapéutico,
Melanoma/tratamiento farmacológico,
Melanoma/secundario,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología,
Antineoplásicos/farmacología,
Protocolos de Quimioterapia Combinada Antineoplásica,
Melanoma/genética,
Quinasas de Proteína Quinasa Activadas por Mitógenos/antagonistas & inhibidores,
Terapia Molecular Dirigida,
Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores,
Neoplasias Cutáneas/genética
