Heart failure with preserved ejection fraction (HFPEF) has become the main phenotypic model of heart failure (HF) in community and referral patients in Brazil and in the world. Despite advances in the development of new drugs for HF treatment, there has been no significant improvement in mortality of thi...
Insuficiencia Cardíaca/fisiopatología,
Fenotipo,
Volumen Sistólico,
Aprendizaje Automático,
Inteligencia Artificial,
Terapéutica/métodos,
Factores de Riesgo,
Diabetes Mellitus,
Obesidad,
Enfermedad Pulmonar Obstructiva Crónica,
Insuficiencia Renal Crónica,
Fibrilación Atrial
Arrhythmogenic right ventricular dysplasia is a classic form of chronic myocardial disease with a broad phenotypical spectrum. We report an atypical case of a patient with biventricular arrhythmogenic cardiomyopathy. Although the current diagnosis criteria are the most widely accepted ones, they focus s...
Abstract Background: Obesity is recognized as a major risk factor for the development of several metabolic complications. However, some obese individuals have a favorable metabolic profile. Objective: The aim of this study was to identify an easy parameter for recognizing metabolically healthy obese (MHO...
Biomarcadores/metabolismo,
Glucemia/análisis,
Índice de Masa Corporal,
Exactitud de los Datos,
Insulina/sangre,
Resistencia a la Insulina,
Grasa Intraabdominal/metabolismo,
Síndrome Metabólico/diagnóstico,
Síndrome Metabólico/metabolismo,
Obesidad/diagnóstico,
Obesidad/metabolismo,
Fenotipo,
Sensibilidad y Especificidad,
Triglicéridos/sangre,
Circunferencia de la Cintura
ABSTRACT Background: The rate of methicillin-resistant Staphylococcus aureus (MRSA) among the total of S. aureus isolates decreased to 35.3% in 2017 in China. It is unclear whether the molecular characteristics of S. aureus isolates have changed as the rate decreased. Objective: This study aimed to inv...
Bacteriemia/virología,
Genotipo,
Staphylococcus aureus Resistente a Meticilina/genética,
Staphylococcus aureus Resistente a Meticilina/patogenicidad,
Pruebas de Sensibilidad Microbiana,
Tipificación Molecular,
Tipificación de Secuencias Multilocus,
Fenotipo,
Staphylococcus aureus/genética,
Staphylococcus aureus/patogenicidad,
Virulencia/genética,
Factores de Virulencia/genética
ABSTRACT Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is spreading worldwide, but little is known about the epidemiology of this pathogen in Brazil. Objective: To evaluate clinical and microbiological features of children with S. aureus infections admitted to a...
Antibacterianos/uso terapéutico,
Brasil/epidemiología,
Infecciones Comunitarias Adquiridas/tratamiento farmacológico,
Infecciones Comunitarias Adquiridas/epidemiología,
Infecciones Comunitarias Adquiridas/microbiología,
Estudios Transversales,
Incidencia,
Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación,
Fenotipo,
Valores de Referencia,
Estudios Retrospectivos,
Factores de Riesgo,
Infecciones Estafilocócicas/tratamiento farmacológico,
Infecciones Estafilocócicas/epidemiología,
Infecciones Estafilocócicas/microbiología,
Estadísticas no Paramétricas,
Factores de Tiempo
ABSTRACT Objective: To determine the role of extended-spectrum β-lactamases in carbapenem-resistant Gram-negative bacteria from south-western Nigeria. Methods: Twenty-seven carbapenem-resistant isolates that were found to be non-carbapenemase producers (15 Escherichia coli, 9 Klebsiella pneumoniae...
Escherichia coli/efectos de los fármacos,
Klebsiella pneumoniae/efectos de los fármacos,
Pseudomonas aeruginosa/efectos de los fármacos,
Fenotipo,
Genotipo,
beta-Lactamasas/biosíntesis,
Escherichia coli/enzimología,
Klebsiella pneumoniae/enzimología,
Pseudomonas aeruginosa/enzimología,
Nigeria,
Pruebas de Sensibilidad Microbiana,
Antibacterianos/farmacología,
Farmacorresistencia Microbiana
Abstract INTRODUCTION: Health care-associated infections caused by metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa are a significant growing concern in patients with burns worldwide. The aims of this study were to determine the antibiotic susceptibility of and detect the presence of MBLs...
Antibacterianos/farmacología,
Quemaduras/microbiología,
Estudios Transversales,
Farmacorresistencia Bacteriana Múltiple,
Pruebas de Sensibilidad Microbiana,
Persona de Mediana Edad,
Fenotipo,
Infecciones por Pseudomonas/microbiología,
Pseudomonas aeruginosa/efectos de los fármacos,
Pseudomonas aeruginosa/enzimología,
beta-Lactamasas/metabolismo
SUMMARY Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two sibl...
Hiperinsulinismo Congénito/genética,
Hiperinsulinismo Congénito/terapia,
Diazóxido/uso terapéutico,
Genotipo,
Mutación/genética,
Pancreatectomía/métodos,
Fenotipo,
Hermanos,
Somatostatina/análisis,
Receptores de Sulfonilureas/genética,
Resultado del Tratamiento
ABSTRACT Objective: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil. Methods: A cross-sectional study of patients with an A1AT gene mutation compatible with deficiency. We evaluated th...
El sistema Rh es altamente polimórfico y está relacionado con la producción de aloanticuerpos y la enfermedad hemolítica del recién nacido. Los antígenos codificados por los genes RHD y RHCE forman el fenotipo Rh que es característico en cada población. Las variantes RHCE no han sido identificada...
