Abstract: Cost-effectiveness analysis is essential in health decision making. Several countries use it as synthesis of evidence to incorporate health technologies. The protease inhibitors (PI) boceprevir (BOC) and telaprevir (TVR) are indicated for chronic hepatitis C treatment and were incorporated in g...
Antivirales/economía,
Antivirales/uso terapéutico,
Brasil,
Análisis Costo-Beneficio,
Quimioterapia Combinada,
Genotipo,
Hepacivirus,
Hepatitis C Crónica/tratamiento farmacológico,
Hepatitis C Crónica/economía,
Interferón alfa-2,
Interferón-alfa,
Oligopéptidos,
Polietilenglicoles,
Prolina/análogos & derivados,
Años de Vida Ajustados por Calidad de Vida,
Proteínas Recombinantes,
Ribavirina
ABSTRACT Objective: To identify phenylalanine hydroxylase (PAH) mutations in patients with phenylketonuria (PKU) from the Newborn Screening Service in Mato Grosso, Midwest Brazil. Methods: This is a cross-sectional descriptive study. The sample consisted of 19 PKU patients diagnosed by newborn screen...
Alelos,
Empalme Alternativo,
Brasil,
Estudios Transversales,
Análisis Mutacional de ADN/métodos,
Genotipo,
Mutación Missense,
Tamizaje Neonatal,
Fenotipo,
Fenilalanina Hidroxilasa/genética,
Fenilcetonurias/genética,
Polimorfismo de Longitud del Fragmento de Restricción
Introduction: Despite the emergence of new treatments for HCV genotype 3 (HCV G3),
there is still a lack of data about this particular subgroup in Brazil. Our objective was
to describe clinical and sociodemographic variables and treatment profile of HCV G3
Brazilian patients.
Methods: This was a descript...
Hepatitis C/virología,
Ribavirina/uso terapéutico,
Genotipo,
Estudios Retrospectivos,
Hepatitis C/epidemiología,
Hepatitis C/tratamiento farmacológico,
Sofosbuvir/uso terapéutico,
Hepacivirus/genética,
Interferones/uso terapéutico,
Antivirales/uso terapéutico,
Cirrosis Hepática/tratamiento farmacológico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Privación de Tratamiento
Propósito/Contexto. Hoy en día, con la posibilidad de detectar la predisposición genética de un número cada vez mayor de enfermedades, incluidos los ampliamente promocionados a nivel mundial y conocidos como “test genéticos del hogar”, la genómica comienza a plantear conflictividades que no se...
SUMMARY OBJECTIVE To explore the association of brain-derived neurotrophic factor gene (BDNF) polymorphism with the latent cognitive endophenotype of posttraumatic stress disorder (PTSD) after major natural disasters in Hainan Province, China. METHODS A total of 300 patients with PTSD and 150 healthy...
Wiśniewska, Halina;
Majka, Maciej;
Kwiatek, Michał;
Gawłowska, Magdalena;
Surma, Maria;
Adamski, Tadeusz;
Kaczmarek, Zygmunt;
Drzazga, Tadeusz;
Ługowska, Bogusława;
Korbas, Marek;
Belter, Jolanta.
BACKGROUND: Wheat is one of the most important crops cultivated all over the world. New high-yielding cultivars that are more resistant to fungal diseases have been permanently developed. The present study aimed at the possibility of accelerating the process of breeding new cultivars, resistant to eyespo...
Background: Growth hormone plays a significant role in determining craniofacial morphology. Mutations of its receptor gene might be associated with mandibular prognathism (MP). Purpose: The aim of the current study was to evaluate growth hormone receptor (GHR) gene polymorphisms in relation to facial dim...
Mandíbula/anatomía & histología,
Cefalometría/métodos,
Polimorfismo de Nucleótido Simple/genética,
Distribución de Chi-Cuadrado,
Prevalencia,
Genotipo,
Irán/etnología,
Base del Cráneo/anatomía & histología,
Maloclusión,
Maloclusión de Angle Clase III/genética,
Hormona del Crecimiento,
Prognatismo
Introdução: fibrose cística (FC) é uma doença genética que culmina em alterações na proteína transmembrana CFTR, resultando na produção de muco mais espesso em diversos órgãos, destacando-se os tratos respiratório e digestório. A insuficiência pancreática (IP) acomete até 95% dos pacien...
Studies on the determination of genetic divergence among genotypes are important tools in breeding programs, contributing to the identification of parents with considerable productive potential. However, little is known about the combinatorial capacity of sweet potato (Ipomoea batatas) access...
Abstract Introduction: HIV replication and the suboptimal use of antiretrovirals are directly related to the appearance of resistant mutations. The objective of this study was to describe the resistance mutations (RMs) present in HIV infected patients who experienced antiretroviral treatment failure bet...
