O adenocarcinoma gástrico associado ao vírus Epstein-Barr (EBV) corresponde a cerca de 10% dos carcinomas gástricos, ocorre mais frequentemente em pacientes mais jovens e acomete preferencialmente a porção proximal do estômago. São tumores que com maior frequência exibem um crescimento sólido, a...
Mammadov, Renad;
Suleyman, Bahadir;
Altuner, Durdu;
Demirci, Elif;
Cetin, Nihal;
Yilmaz, Adnan;
Baykal, Huseyin;
Alpcan, Hilal;
Turumtay, Emine Akyuz;
Suleyman, Halis.
Abstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esopha...
MicroRNAs (miRNAs), as post-transcriptional regulators, have been reported to be involved in the initiation and progression of various types of cancer, including gastric cancer (GC). The present study aimed to investigate the role of miR-383-5p in gastric carcinogenesis. Cell viability was analyzed using...
Apoptosis,
Carcinogénesis/genética,
Carcinoma/genética,
Carcinoma/metabolismo,
Carcinoma/patología,
Proliferación Celular/genética,
Progresión de la Enfermedad,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
Histona Desacetilasas/metabolismo,
MicroARNs/metabolismo,
Estadificación de Neoplasias,
ARN Mensajero/metabolismo,
Proteínas Represoras/metabolismo,
Neoplasias Gástricas/genética,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as...
Fibroblast growth factor receptor 1 (FGFR1) has been reported in gastric cancer to be a prognostic factor. However, miR-497-targeted FGFR1 has not been explored in the carcinogenesis of gastric cancer. The present study intended to revalidate the prognostic significance of FGFR1 in patients with gastric ...
Apoptosis,
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular,
Progresión de la Enfermedad,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
MicroARNs/metabolismo,
Pronóstico,
ARN Mensajero/genética,
ARN Mensajero/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos/genética,
Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos/metabolismo,
Transducción de Señal,
Neoplasias Gástricas/genética,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología
OBJETIVO Describir las características clínicas, los patrones de tratamiento y los costos asociados en pacientes con cáncer gástrico localmente avanzado o metastásico en Argentina, en los sectores público y privado. MÉTODOS Una cohorte histórica de pacientes que recibieron tratamiento de quimiote...
Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación,
Gastrectomía/métodos,
Neoplasias Gástricas/epidemiología,
Argentina,
Estudios de Cohortes,
Estudios de Seguimiento,
Costos de Hospital/estadística & datos numéricos,
Metástasis de la Neoplasia,
Estadificación de Neoplasias,
Estudios Retrospectivos,
Neoplasias Gástricas/patología,
Neoplasias Gástricas/terapia
BACKGROUND: Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to identify patients at risk of poor prognoses. METHODS: Tissue microarrays were used to m...
Biomarcadores de Tumor/metabolismo,
Proteínas de Neoplasias/metabolismo,
Neoplasias Gástricas/mortalidad,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Estadificación de Neoplasias,
Pronóstico,
Análisis de Supervivencia,
Análisis de Matrices Tisulares
BACKGROUND: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between...
Biomarcadores de Tumor/metabolismo,
Receptor ErbB-3/metabolismo,
Neoplasias Gástricas/metabolismo,
Genes erbB-1,
Receptor ErbB-3/genética,
Neoplasias Gástricas/mortalidad,
Neoplasias Gástricas/patología,
Regulación Neoplásica de la Expresión Génica,
Genes erbB,
Inmunohistoquímica,
Pronóstico,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Tasa de Supervivencia
Gastric cancer (GC) is the third most lethal type of cancer worldwide. Single nucleotide polymorphisms (SNPs) in regulatory sites or coding regions can modify the expression of genes involved in gastric carcinogenesis, as ERBB2, which encodes for the tyrosine-kinase receptor HER-2. The aim of this work w...
We determined the effects of enhanced recovery after surgery (ERAS) in patients undergoing radical surgery for gastric carcinoma. Sixty patients undergoing radical gastrectomy for gastric carcinoma in Lishui Hospital between March and October 2016 were randomized to receive either ERAS (30 patients) or c...
