Echeverría, Luis Eduardo;
González, Clara Isabel;
Hernandez, Julio Cesar Mantilla;
Díaz, Martha Lucia;
Eduardo Nieto, Javier;
López-Romero, Luis Alberto;
Rivera, Julián David;
Suárez, Edwin Uriel;
Ochoa, Sergio Alejandro Gómez;
Rojas, Lyda Z;
Morillo, Carlos A.
Abstract INTRODUCTION: Benznidazole (BZL) and Nifurtimox (NFX) are the pharmacological treatment for acute phase Chagas Disease (CD); however, therapy resistance and residual mortality development remain important unresolved issues. Posaconazole (POS) has shown a trypanocidal effect in vivo and in vitr...
Enfermedad Aguda,
Enfermedad de Chagas/tratamiento farmacológico,
ADN Protozoario,
Modelos Animales de Enfermedad,
Progresión de la Enfermedad,
Quimioterapia Combinada,
Nitroimidazoles/administración & dosificación,
Carga de Parásitos,
Parasitemia/tratamiento farmacológico,
Ratas Wistar,
Triazoles/administración & dosificación,
Tripanocidas/administración & dosificación
Abstract INTRODUCTION: Congenital transmission (CT) of Trypanosoma cruzi has led to globalization of Chagas disease and its growing relevance as a public health problem. Although the occurrence of CT has been associated with several factors, its mechanisms are still unknown. This study aimed to analyze...
Abstract Introduction: The genus Rhodnius in the subfamily Triatominae comprises 20 species, which can transmit Trypanosoma cruzi and Trypanosoma rangeli. Due to the development of molecular techniques, Triatominae species can now be characterized by mitochondrial and nuclear markers, making it possibl...
Lopes, Luiza Braz da Cunha;
Pereira, Raquel Rodrigues;
Andrade, Patricia Mello;
Carneiro, Fernanda Martins;
Mediano, Mauro Felippe Felix;
Kilgore, Sophia Isabel Linnemann;
Hasslocher-Moreno, Alejandro Marcel;
Sousa, Andréa Silvestre de;
Oliveira, Manoel Marques Evangelista;
Saraiva, Roberto Magalhães;
Holanda, Marcelo Teixeira de;
Silva, Gilberto Marcelo Sperandio da.
Abstract INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regres...
RESUMEN Introducción. La enfermedad de Chagas o tripanosomiasis americana es causada por el protozoo flagelado Trypanosoma cruzi, transmitido principalmente por insectos vectores (denominados popularmente en las diferentes zonas de la Región de las Américas "vinchucas", "pitos", "chinches", "chirimac...
Abstract INTRODUCTION: Triatomines are hematophagous insects of epidemiological importance because they are vectors of Chagas disease. We present here the first report of Rhodnius montenegrensis in Amazonas, Brazil. METHODS: Triatomines were collected from Attalea butyracea palm trees in the municipal...
Actualmente, la transmisión transplacentaria
es la vía más frecuente de infección por Trypanosoma cruzi. El diagnóstico y tratamiento temprano de hijos infectados evita el riesgo de desarrollar
miocardiopatía y las niñas dejan de ser potenciales fuentes de transmisión congénita. En este estudio ...
The use of linear mixed models for nested structure longitudinal data is called hierarchical linear modeling. Thismodeling takes into account the dependence of existing data within each level and between hierarchical levels. The process of modeling, estimating and analyzing diagnoses was ill...
Abstract Objective: To analyze the spatial distribution of Acute Chagas Disease (ACD) cases in a riverside municipality and make relationships with the notifying health services. Method: Longitudinal, ecological, quantitative study with use of geoprocessing techniques, conducted with cases of acute C...
