ABSTRACT This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin comb...
Antibacterianos/farmacología,
Cefalosporinas/farmacología,
Infección Hospitalaria/microbiología,
Farmacorresistencia Bacteriana Múltiple,
Enterobacteriaceae/clasificación,
Enterobacteriaceae/efectos de los fármacos,
Enterobacteriaceae/aislamiento & purificación,
Monitoreo Epidemiológico,
América Latina,
Ácido Penicilánico/análogos & derivados,
Ácido Penicilánico/farmacología,
Fenotipo,
Pseudomonas aeruginosa/efectos de los fármacos,
Pseudomonas aeruginosa/aislamiento & purificación,
Tazobactam
Matsuzaka, Camila T;
Christofolini, Denise;
Ota, Vanessa K;
Gadelha, Ary;
Berberian, Arthur A;
Noto, Cristiano;
Mazzotti, Diego R;
Spindola, Leticia M;
Moretti, Patricia N;
Smith, Marilia A C;
Melaragno, Maria I;
Belangero, Sintia I;
Bressan, Rodrigo A.
Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cog...
Estudios de Casos y Controles,
Catecol O-Metiltransferasa/genética,
Catecol O-Metiltransferasa/metabolismo,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Haplotipos,
Memoria a Corto Plazo/fisiología,
Pruebas Neuropsicológicas,
Fenotipo,
Polimorfismo de Nucleótido Simple/genética,
Corteza Prefrontal/metabolismo,
Esquizofrenia/genética,
Esquizofrenia/metabolismo,
Esquizofrenia/fisiopatología
ABSTRACT BACKGROUND: Endoscopic mucosal resection is still considered an accepted treatment for early gastric cancer for selected cases. Histopathologic criteria for curative endoscopic resection are intramucosal well-differentiated adenocarcinoma, lateral and deep margins free of tumor, no histological...
Adenocarcinoma/clasificación,
Adenocarcinoma/metabolismo,
Adenocarcinoma/cirugía,
Biomarcadores de Tumor/metabolismo,
Resección Endoscópica de la Mucosa,
Mucosa Gástrica/patología,
Mucosa Gástrica/cirugía,
Antígeno Ki-67/metabolismo,
Persona de Mediana Edad,
Mucinas,
Recurrencia Local de Neoplasia/metabolismo,
Fenotipo,
Neoplasias Gástricas/clasificación,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/cirugía,
Proteína p53 Supresora de Tumor/metabolismo
Correa, Fernanda A;
França, Marcela M;
Fang, Qing;
Ma, Qianyi;
Bachega, Tania A;
Rodrigues, Andresa;
Ozel, Bilge A;
Li, Jun Z;
Mendonca, Berenice B;
Jorge, Alexander A L;
Carvalho, Luciani R;
Camper, Sally A;
Arnhold, Ivo J P.
SUMMARY Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7.5 year-old boy born to secon...
Hiperplasia Suprarrenal Congénita/complicaciones,
Hiperplasia Suprarrenal Congénita/genética,
Enfermedades del Desarrollo Óseo/etiología,
Enfermedades del Desarrollo Óseo/genética,
Consanguinidad,
Enanismo Hipofisario/complicaciones,
Enanismo Hipofisario/genética,
Mutación,
Linaje,
Fenotipo,
Receptores de Neuropéptido/genética,
Receptores de Hormona Reguladora de Hormona Hipofisaria/genética,
Esteroide 21-Hidroxilasa/genética
ABSTRACT Objective Adipokines are mediators of body composition and are involved in obesity complications. This study aimed to assess the association of circulating omentin-1, vaspin, and RBP-4 with body composition indices and metabolic health status (MHS) in different phenotypes of body size. Subjec...
Composición Corporal,
Índice de Masa Corporal,
Tamaño Corporal,
Estudios Transversales,
Citocinas/sangre,
Ensayo de Inmunoadsorción Enzimática,
Proteínas Ligadas a GPI/sangre,
Lectinas/sangre,
Obesidad/sangre,
Obesidad/metabolismo,
Fenotipo,
Proteínas Plasmáticas de Unión al Retinol/análisis,
Serpinas/sangre
O objetivo deste trabalho é fazer uma revisão atual de uma medicina de precisão personalizada e dirigida para fenótipos e endótipos de asma. As fontes de dados incluíram artigos originais, revisões e publicações indexadas nos bancos de dados PubMed, MEDLINE, LILACS, SciELO e publicadas on line n...
Asma,
Terapéutica,
Medicina de Precisión,
Fenotipo,
Interleucina-13,
Interleucina-5,
LILACS,
MEDLINE,
Pacientes,
Inmunoglobulina E,
Inmunidad,
Esteroides
Abstract Chromosome stoichiometry, a form of genetic plasticity, specifically refers to variation in the standard diploid genomic composition of an individual or species. In the present work, freshwater planarians (Girardia schubarti) were analyzed to recognize variations in chromosomal stoichiometry esp...
BACKGROUND Mycobacterium tuberculosis (MTB) is one of the most significant causes of mortality and morbidity. Early diagnose is important especially in multiple drug resistant tuberculosis to avoid transmission. Traditional techniques requires at least one to three weeks for diagnosis of tuberculosis. Di...
Abstract The clinical management and decision-making in pregnancies in which there is suspicion of lethal fetal malformations during the prenatal period, such as lethal skeletal dysplasia (SD), demand a multidisciplinary approach coordinated by an experienced physician. Based on the presentation of a cas...
Resumen: Introducción: La leucoencefalopatía con sustancia blanca evanescente es una de las leucodistrofias más frecuentes. Generalmente inicia en la infancia y presenta un patrón de herencia autosómica recesiva. El 90% de los casos manifiesta mutaciones en uno de los genes que codifican para las ...
