Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell damage that affects the retinal circulation. In turn, ...
Retinopatía Diabética/tratamiento farmacológico,
Inhibidores de Serina Proteinasa/uso terapéutico,
alfa 1-Antitripsina/uso terapéutico,
Antiinflamatorios/metabolismo,
Antiinflamatorios/uso terapéutico,
Movimiento Celular/fisiología,
Quimiotaxis/fisiología,
Retinopatía Diabética/fisiopatología,
Inflamación/metabolismo,
Mediadores de Inflamación/antagonistas & inhibidores,
FN-kappa B/metabolismo,
Neutrófilos/fisiología,
Óxido Nítrico Sintasa/antagonistas & inhibidores,
Sustancias Protectoras/metabolismo,
Receptores Proteinasa-Activados/metabolismo,
Inhibidores de Serina Proteinasa/metabolismo,
Factor de Necrosis Tumoral alfa/metabolismo,
alfa 1-Antitripsina/metabolismo,
Hipoxia de la Célula,
Radicales Libres
Amorim, Aline Teixeira;
Marques, Lucas Miranda;
Santos, Angelita Maria Oliveira Gusmão;
Martins, Hellen Braga;
Barbosa, Maysa Santos;
Rezende, Izadora Souza;
Andrade, Ewerton Ferraz;
Campos, Guilherme Barreto;
Lobão, Tássia Neves;
Cortez, Beatriz Araujo;
Monezi, Telma Alvez;
Machado-Santelli, Glaucia Maria;
Timenetsky, Jorge.
BACKGROUND: Bacterial pathogens have many strategies for infecting and persisting in host cells. Adhesion, invasion and intracellular life are important features in the biology of mollicutes. The intracellular location ofUreaplasma diversum may trigger disturbances in the host cell. This includes activat...
Apoptosis/fisiología,
Ureaplasma/patogenicidad,
Citoesqueleto de Actina/ultraestructura,
Caspasa 2/metabolismo,
Caspasa 3/metabolismo,
Caspasa 9/metabolismo,
Gentamicinas/farmacología,
Células HeLa/microbiología,
Moléculas de Patrón Molecular Asociado a Patógenos/metabolismo,
Factor de Necrosis Tumoral alfa/metabolismo,
Ureaplasma/efectos de los fármacos,
Infecciones por Ureaplasma/fisiopatología,
Adhesión Bacteriana,
Supervivencia Celular,
Citometría de Flujo,
Expresión Génica,
Microscopía Confocal,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Estadísticas no Paramétricas,
Factores de Tiempo
BACKGROUND: Tuberculosis (TB) is a respiratory tract disease caused by Mycobacterium tuberculosis infection. M. tuberculosis exploits immune privilege to grow and divide in pleural macrophages. Fibrates are associated with the immune response and control lipid metabolism through glycolysis with β-oxidat...
Ácidos Fíbricos/farmacología,
Mediadores de Inflamación/metabolismo,
Macrófagos/efectos de los fármacos,
Infecciones por Mycobacterium/metabolismo,
Mycobacterium smegmatis,
Acetil-CoA C-Acetiltransferasa/metabolismo,
Macrófagos/metabolismo,
Macrófagos/microbiología,
Factor 88 de Diferenciación Mieloide/metabolismo,
PPAR alfa/metabolismo,
Transducción de Señal/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/metabolismo,
Western Blotting,
Células U937
INTRODUCTION: pyoderma gangrenosum (PG) is a rare and severe neutrophilic dermatosis associated with inflammatory bowel disease (IBD) and other systemic diseases such as rheumatoid arthritis and hematological malignancies. Diagnosis is based on clinical criteria and exclusion of other skin disorders. The...
Apathy is intimately associated with dementia. Unfortunately, its pathophysiology remains poorly understood. The motivational impairment that characterizes this disorder might share the same inflammatory mechanisms, as suggested by the sickness behavior theory. OBJECTIVE: The primary aim of this study wa...
Los agentes biológicos inhibidores del factor de necrosis tumoral alfa (anti-TNF) se constituyen en un avance muy significativo en el tratamiento de los pacientes con espondilitis anquilosante (EA), demostrando una notable mejoría de sus síntomas, de su función y de su calidad de vida. Sumado a esta ...
A DOENÇA: A psoríase é uma doença crônica, sistêmica e inflamatória que afeta a pele, semi-mucosas e, em alguns casos, as articulações. Apresenta origem imunológica e predisposição genética, porém a influência de múltiplos fatores ambientais pode levar ao desenvolvimento ou à piora da do...
En el trabajo se exploró el efecto de Arnica montana con diferentes diluciones homeopáticas en muestras de cultivos de sangre periférica de 10 pacientes sanos, midiendo la producción de la citoquina Factor de Necrosis Tumoral - alfa (FNT-α), mediante técnica de ELISA. Las respuestas fueron más alt...
The inflammatory bowel diseases (IBD) are defined as nonspecific chronic intestinal inflammations with possible systemic involvement. IBD have unknown etiology. The inflammatory process is complex and heterogeneous, both as to the characterization of the disease that affects the digestive tract, without ...
Ulcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment...
