ABSTRACT Purpose: Subarachnoid hemorrhage (SAH) is a common complication of cerebral vascular disease. Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy. Autophagy is a programmed cell death mechanism that plays...
ABSTRACT Purpose: Spontaneous intracerebral hemorrhage (ICH) is a major cause of death and disability with a huge economic burden worldwide. Cerebrolysin (CBL) has been previously used as a nootropic drug. Necroptosis is a programmed cell death mechanism that plays a vital role in neuronal cell death af...
Aminoácidos,
Apoptosis,
Hemorragia Cerebral/tratamiento farmacológico,
Glucógeno Sintasa Quinasa 3 beta/farmacología,
Ratones Endogámicos C57BL,
Necroptosis,
Neuronas/metabolismo,
Neuroprotección,
Fármacos Neuroprotectores/farmacología,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Transducción de Señal
Objectives: This study aimed to investigate the neuroprotective effects of the ethanolic extract obtained from red algae marine Meristiella echinocarpa (Areschougiaceae) – EEMe. Methods: EEMe was used in doses ranging from 10 to 40 mg/kg, administered intraperitoneally in mice. Behavioral tests were pe...
It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies. The present study investigated whether the anti-apoptotic effect can account for the neuroprotective action of ZNS on cerebral ischemia. Neuronal ...
Tirapelli, Daniela P. C;
Cirino, Mucio Luiz de Assis;
Carvalho, Camila A. Melo de;
Novais, Paulo Cezar;
Figueredo, Rafael Zimak;
Porsani, Lucas Barbosa;
Gula, Isabella Stracieri;
Rodrigues, Andressa Romualdo;
Silva, Jairo Pinheiro da;
Pereira, Adriana Lis;
Lizarte Neto, Fermino Sanches;
Schimming, Bruno Cesar;
Tazima, Maria de Fátima Galli Sorita;
Fazan, Valéria de Paula Sassoli;
Carlotti-Jr, Carlos Gilberto;
Tirapelli, Luis Fernando;
Colli, Benedicto Oscar.
This study aimed to investigate the morphometric and the pattern of protein and gene expression related to the extrinsic apoptotic pathway in experimental focal cerebral ischemia and the hole of neuroprotection with hypothermia and ketoprofen. For this analysis, 120 rats were randomly divided into 3 grou...
Isquemia Encefálica/terapia,
Isquemia Encefálica/genética,
Apoptosis/genética,
Hipotermia Inducida,
Cetoprofeno/farmacología,
Fármacos Neuroprotectores/farmacología,
Isquemia Encefálica/patología,
Caspasa 8/genética,
Caspasa 3/genética,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Isquemia Encefálica/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa
Current pharmacotherapy of Parkinson's disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients' quality of life with fewer side effects are needed, but not yet available. Cannabidiol (CBD), the major non-psychotomimetic constituent of can...
Abstract Purpose To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions. Methods Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, tr...
Astrocitos/efectos de los fármacos,
Lesiones Traumáticas del Encéfalo/patología,
Lesiones Traumáticas del Encéfalo/prevención & control,
Lesiones Traumáticas del Encéfalo/cirugía,
Proteínas de Unión al Calcio/análisis,
Cinamatos/farmacología,
Craneotomía/métodos,
Depsidos/farmacología,
Proteína Ácida Fibrilar de la Glía/análisis,
Glutatión Peroxidasa/análisis,
Inmunohistoquímica,
Malondialdehído/análisis,
Proteínas de Microfilamentos/análisis,
Fármacos Neuroprotectores/farmacología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Valores de Referencia,
Reproducibilidad de los Resultados
Neurodegeneration is a progressive loss of neurons both structurally and functionally causing neuronal cell death ultimately leading to development of various neurodegenerative diseases. Due to poor pharmacokinetic profile of neurotrophins, there still remains a challenge in their...
Abstract In live organisms, there is a balance between the production of reactive oxygen species (ROS) and their neutralization. The increased level of these species leads to a condition called redox imbalance. The aim of this study was to evaluate the protective action of isobenzofuranones in primary cu...
The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neurotoxic ...
Amidas/agonistas,
Cafeína/antagonistas & inhibidores,
Células/clasificación,
Economía,
Encéfalo/patología,
Fármacos Neuroprotectores/análisis,
Glutatión/farmacología,
Neuroprotección,
Oxidopamina,
Supervivencia Celular,
Sinaptosomas
