Results: 42

Leucemia linfoblástica aguda con grave alteración hepática como manifestación inicial: presentación de dos casos y revisión de la literatura

Rev. méd. Chile; 145 (6), 2017
Hematological diseases may cause acute hepatic failure and are seldom sought. We report two cases illustrating this situation. A 16-year-old male presented with an acute liver failure: a bone marrow biopsy showed complete infiltration with lymphoid type blasts. A flow cytometry confirmed the presence of ...

Action of vitamin e on experimental severe acute liver failure

Arq. gastroenterol; 54 (2), 2017
ABSTRACT BACKGROUND Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in...

Insuficiencia hepática aguda neonatal: un desafío diagnóstico

Arch. argent. pediatr; 115 (2), 2017
La insuficiencia hepática aguda durante el período neonatal es una enfermedad rara, muy grave, con elevada mortalidad. Se diferencia clínica y etiológicamente de la insuficiencia hepática aguda del niño mayor y del adulto. La coagulopatía, con un Rango Internacional Normatizado > 3, es el parámet...

Hemorragia digestiva e insuficiencia hepática aguda por leptospirosis: una entidad que no debemos olvidar

La leptospirosis es una enfermedad causada por la espiroqueta Leptospira. Se trata de una zoonosis de distribución mundial, con predominio en los trópicos. En España no es frecuente pero sí se observan casos en zonas más húmedas o con presencia de ríos, lagos o estanques, como son Cataluña, Andal...

Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population

Braz. j. med. biol. res; 50 (6), 2017
This study aimed to determine the role of mitofusin 2 (MFN2) gene polymorphisms in the risk and prognosis of acute liver failure (ALF). A total of 298 blood samples were collected from 138 ALF patients (case group) and 160 healthy participants (control group). Coagulation function, glutamic pyruvic trans...

Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine

Acta cir. bras; 31 (12), 2016
ABSTRACT PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three grou...

Cardiopulmonary bypass ischemic hepatitis reported in five patients

Abstract Objective: In cardiac surgery, the lung, renal and neurological events are the most frequent complications. Less common, acute liver failure is a serious complication that adds high morbidity, mortality, and costs. Therefore, this communication aimed to retrospectively evaluate five patients wh...

ERK 1/2 activation does not contribute to increased survival mediated by bone marrow cells after 90% partial hepatectomy in Wistar rats

Clin. biomed. res; 36 (4), 2016
We investigated the influence of bone marrow cells upon activation of ERK 1/2 in an animal model of 90% PH. Phosphorylated ERK 1/2 was evaluated by western blot. No differences were found between the groups. Thus, increased survival does not appear to be mediated by ERK 1/2 activation (AU)...

Estudo de gene da lectina ligadora de manose em doador falecido e transplante de fígado - relato de caso

A hepatite autoimune é uma doença de curso crônico e etiologia ainda não esclarecida, que em alguns casos evolui para falência hepática aguda, condição em que o tratamento definitivo é o transplante hepático. Assumidos todos os riscos da cirurgia, restam ainda outras variáveis que concorrem pa...

Insuficiência hepática aguda secundária à infecção pelo vírus Epstein-Barr

Introdução: a infecção pelo vírus Epstein-Barr (EBV) possui prevalência elevada, com mais de 90% da população mundial soropositiva. Em geral, é doença benigna, mas pode cursar com complicações. A alteração de transaminases é comum no curso da doença, mas hepatite fulminante é complicaç...