Results: 65

Altered Tregs and oxidative stress in pregnancy associated lupus

Adv Rheumatol; 59 (), 2019
Abstract Aim SLE is a systemic autoimmune disease generally affecting woman in the reproductive age. It is associated with an altered level of Tregs and oxidative stress while an increase in Tregs, and different antioxidant mechanisms to combat oxidative stress are essential for successful pregnancy. H...

CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice

Adv Rheumatol; 59 (), 2019
Abstract Background: Adaptive immune cells, including CD4+CD69+ and CD4+CD25+FoxP3+ regulatory T (Treg) cells, are important for maintaining immunological tolerance. In human systemic lupus erythematosus (SLE), CD4+CD25+FoxP3+ Treg cells are reduced, whereas CD69 expression is increased, resulting in a ...

Criptococcosis en el Hospital Carlos Van Buren de Valparaíso: una serie de casos

Rev. chil. infectol; 35 (4), 2018
Resumen Introducción: La criptococcosis es una infección micótica oportunista grave, Cryptococcus neoformans es la principal especie de importancia médica, pudiendo manifestarse como meningitis, neumonía o criptococcemia. Objetivo: Caracterizar a los pacientes con infección por Cryptococcus sp. e...

Mecanismos epigenéticos en la plasticidad y flexibilidad de los linfocitos T CD4
Epigenetic mechanisms in plasticity and flexibility of the CD4 T cells

Watson y Crick descifraron en 1953 la estructura del ácido desoxirribonucleico (ADN), a partir de ese momento se produjo una revolución en el campo de la Biología Molecular y la Genética, cuyo colofón fue la publicación de la primera versión del genoma humano en el año 2001. Sin embargo, esto sol...

Non-polarized cytokine profile of a long-term non-progressor HIV infected patient

Braz. j. infect. dis; 22 (2), 2018
ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy...

Influência de TLR3 em modelo de Paracoccidioidomicose experimental

Os receptores do tipo Toll compreendem a família de receptores de reconhecimento de padrões melhor caracterizados, que podem ativar diferentes respostas imunes, dependendo de quais receptores e conjuntos de adaptadores são utilizados. Os TLRs, como TLR2, TLR4 e TLR9, e sua sinalização foram implicad...

Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations

Braz. j. infect. dis; 21 (6), 2017
ABSTRACT Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is ind...

Role of T. cruzi exposure in the pattern of T cell cytokines among chronically infected HIV and Chagas disease patients

Clinics; 72 (11), 2017
OBJECTIVES: The impact of Chagas disease (CD) in HIV-infected patients is relevant throughout the world. In fact, the characterization of the adaptive immune response in the context of co-infection is important for predicting the need for interventions in areas in which HIV and Chagas disease co-exist. ...

Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease

Abstract INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. METHODS: The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ ...

Atorvastatin-medicated dentifrice significantly inhibits CD4+ T cell proliferation: in vitro pilot study

Int. j. morphol; 35 (2), 2017
Reports indicate that statins (cholesterol-lowering drugs), in addition to lowering cholesterol, have an immunomodulatory effect. This effect may be beneficial for the treatment of several diseases, including periodontal disease. The aim of the present study was to evaluate the immunomodulatory effect of...