Results: 35

Granulomatous slack skin: a rare subtype of mycosis fungoides

An. bras. dermatol; 92 (5), 2017
Abstract: We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histol...

Primary cutaneous follicle center lymphoma

An. bras. dermatol; 92 (5), 2017
Abstract: Cutaneous lymphomas are classified according to their cellular origin into T-cell lymphoma and B-cell lymphoma. The annual incidence rate is 0.3 per 100,000 population. We report a case of a 56-year-old male patient who presented with a two-month history of nodules of varying sizes, some ulcera...

Melanoma: tumor microenvironment and new treatments

An. bras. dermatol; 92 (2), 2017
Abstract: In the recent past years, many discoveries in the tumor microenvironment have led to changes in the management of melanoma and it is rising up hopes, specially, to those in advanced stages. FDA approved seven new drugs from 2011 to 2014. They are: Vemurafenib, Dabrafenib and Trametinib, kinases...

Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells

Braz. j. med. biol. res; 50 (7), 2017
Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural ana...

Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids

An. bras. dermatol; 92 (5,supl.1), 2017
Abstract: Clear cell acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral presentation. We here report the first case of bilateral clear cell acanthoma with good response to topical corticosteroids. Case report:...

Hyperpigmentation as a peculiar presentation of mycosis fungoides

An. bras. dermatol; 92 (5,supl.1), 2017
Abstract Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry. This report describes a typical case of hyperpigmented mycosis...

Entendiendo las terapias actuales en melanoma metastásico

Rev. méd. Chile; 144 (11), 2016
Cutaneous melanoma is a highly aggressive tumor developing from melanocytes, its incidence is increasing, and prognosis in advanced stages is daunting. New therapies have been approved during the recent years with unprecedented results, including inhibitors of MAPK/ERK pathway and immune checkpoint block...

Alemtuzumab in refractory Sézary syndrome

An. bras. dermatol; 91 (5), 2016
Abstract: Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by the triad of erythroderma, lymphadenopathy and circulating atypical cells. The emergence of new molecular targets has enabled the development of drugs such as alemtuzumab, an anti-CD52 monoclonal antibody, which has shown ...

Multifocal primary cutaneous extranodal NK/T lymphoma nasal type

An. bras. dermatol; 91 (2), 2016
Abstract Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites,...