Abstract: We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histol...
Antineoplásicos Hormonales/uso terapéutico,
Biopsia,
Inmunohistoquímica,
Linfoma Cutáneo de Células T/diagnóstico,
Linfoma Cutáneo de Células T/tratamiento farmacológico,
Linfoma Cutáneo de Células T/patología,
Fotograbar,
Prednisona/uso terapéutico,
Neoplasias Cutáneas/diagnóstico,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología
Abstract: Cutaneous lymphomas are classified according to their cellular origin into T-cell lymphoma and B-cell lymphoma. The annual incidence rate is 0.3 per 100,000 population. We report a case of a 56-year-old male patient who presented with a two-month history of nodules of varying sizes, some ulcera...
Biopsia,
Eritema/etiología,
Neoplasias Faciales/tratamiento farmacológico,
Neoplasias Faciales/patología,
Resultado Fatal,
Hemangiosarcoma/tratamiento farmacológico,
Hemangiosarcoma/patología,
Inmunohistoquímica,
Piel/patología,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología
Abstract: In the recent past years, many discoveries in the tumor microenvironment have led to changes in the management of melanoma and it is rising up hopes, specially, to those in advanced stages. FDA approved seven new drugs from 2011 to 2014. They are: Vemurafenib, Dabrafenib and Trametinib, kinases...
Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural ana...
Abstract: Clear cell acanthoma is a rare, epidermal tumor not common in the area of the nipples; indeed, the literature describes only 8 cases, all showing unilateral presentation. We here report the first case of bilateral clear cell acanthoma with good response to topical corticosteroids. Case report:...
Acantoma/tratamiento farmacológico,
Acantoma/patología,
Administración Tópica,
Biopsia,
Clobetasol/administración & dosificación,
Glucocorticoides/administración & dosificación,
Neoplasias Primarias Múltiples/tratamiento farmacológico,
Neoplasias Primarias Múltiples/patología,
Pezones/patología,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología,
Resultado del Tratamiento
Abstract Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry. This report describes a typical case of hyperpigmented mycosis...
Biopsia,
Linfocitos T CD8-positivos/patología,
Hiperpigmentación/tratamiento farmacológico,
Hiperpigmentación/patología,
Inmunohistoquímica,
Micosis Fungoide/tratamiento farmacológico,
Micosis Fungoide/patología,
Terapia PUVA/métodos,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología,
Resultado del Tratamiento
Cutaneous melanoma is a highly aggressive tumor developing from melanocytes, its incidence is increasing, and prognosis in advanced stages is daunting. New therapies have been approved during the recent years with unprecedented results, including inhibitors of MAPK/ERK pathway and immune checkpoint block...
Antineoplásicos/uso terapéutico,
Melanoma/tratamiento farmacológico,
Melanoma/secundario,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología,
Antineoplásicos/farmacología,
Protocolos de Quimioterapia Combinada Antineoplásica,
Melanoma/genética,
Quinasas de Proteína Quinasa Activadas por Mitógenos/antagonistas & inhibidores,
Terapia Molecular Dirigida,
Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores,
Neoplasias Cutáneas/genética
Abstract: Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by the triad of erythroderma, lymphadenopathy and circulating atypical cells. The emergence of new molecular targets has enabled the development of drugs such as alemtuzumab, an anti-CD52 monoclonal antibody, which has shown ...
Abstract Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites,...
Linfoma Extranodal de Células NK-T/patología,
Neoplasias Primarias Múltiples/patología,
Neoplasias Nasales/patología,
Neoplasias Cutáneas/patología,
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico,
Biopsia,
Ciclofosfamida/uso terapéutico,
Doxorrubicina/uso terapéutico,
Resultado Fatal,
Linfoma Extranodal de Células NK-T/tratamiento farmacológico,
Neoplasias Primarias Múltiples/tratamiento farmacológico,
Neoplasias Nasales/tratamiento farmacológico,
Prednisona/uso terapéutico,
Piel/patología,
Neoplasias Cutáneas/tratamiento farmacológico,
Vincristina/uso terapéutico