Results: 467

Eficacia y seguridad del uso de pertuzumab en combinación con trastuzumab y docetaxel para el tratamiento de pacientes con cáncer de mama metastáscio HER2 positivo sin terapia sistémica previa
Efficacy and safety of the use of pertuzumab in combination with trastuzumab and docetaxel for the treatment of patients with HER2 positive metastatic breast cancer without previous systemic therapy

INTRODUCCIÓN: Antecedentes: El presente dictamen expone la evaluación de tecnología de la eficacia y seguridad del uso de pertuzumab en combinación a trastuzumab y docetaxel (P+T+D), apra el tratamiento de pacientes adultos con cáncer de mama metastásico HER 2 positivo, sin terapia sistémica previ...

Eficacia y seguridad de brentuximab vedotin en el tratamiento de pacientes con linfoma anaplásico de células T alk negativo con progressión de enfermedad a m´s de 2 líneas de qumioterapia

INTRODUCCIÓN: Antecedentes: El present dictamen expone la evaluación de tecnología de l eficacia y seguridad de brentuximab vedotin en el tratamiento de pacientes con linfoma anaplásico de células T sistémico ALK negativo con progresión de enfermedad a más de 2 líneas de quimioterapia. Aspectos ...

A "miracle" cancer drug in the era of social media: A survey of Brazilian oncologists' opinions and experience with phosphoethanolamine

Summary Introduction: Patients who are treating cancer have often used alternative therapies. In the internet era, information can be broadcasted widely, and this happened with phosphoethanolamine in Brazil, where this substance was claimed by the population to be the "cure for cancer." Method: This is...

Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway

Braz. j. med. biol. res; 50 (7), 2017
As an active constituent of the beetle Mylabris used in traditional Chinese medicine, cantharidin is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays a crucial role in cell cycle progression, apoptosis, and cell fate. The role and possible mechanisms exerted by cantharidin in ...

Neoadjuvant chemotherapy with trastuzumab in HER2-positive breast cancer: pathologic complete response rate, predictive and prognostic factors

Braz. j. med. biol. res; 50 (2), 2017
The purpose of this study was to retrospectively review the pathologic complete response (pCR) rate from patients (n=86) with stage II and III HER2-positive breast cancer treated with neoadjuvant chemotherapy at our institution from 2008 to 2013 and to determine possible predictive and prognostic factors...

MicroRNA-340-5p modulates cisplatin resistance by targeting LPAATβ in osteosarcoma

Braz. j. med. biol. res; 50 (5), 2017
MicroRNAs (miRNAs) play an important role in drug resistance and modulate the efficiency of chemotherapy. A recent study indicated that miR-340 functions as a tumor suppressor in various types of cancer. However, the role of miR-340 in chemotherapy has not been reported yet. In this study, we found that ...

Establishment of patient-derived tumor xenograft (PDTX) models using samples from CT-guided percutaneous biopsy

Braz. j. med. biol. res; 50 (6), 2017
This study aimed to investigate the feasibility of the establishment of a human cancer xenograft model using samples from computed tomography (CT)-guided percutaneous biopsy. Fresh tumor tissues obtained from 10 cancer patients by CT-guided percutaneous biopsy were subcutaneously inoculated into NOD-Prkd...

Emergência oncológica: atuação dos enfermeiros no extravasamento de drogas quimioterápicas antineoplásicas
Oncological emergency: the work of nurses in the extravasation of antineoplastic chemotherapeutic drugs

Objetivo: Investigar a atuação dos enfermeiros no extravasamento de quimioterápicos antineoplásicos. Métodos: Estudo transversal, com abordagem quantitativa, realizado em um hospital de referência em oncologia, com uma amostra de 21 enfermeiros. Os dados foram coletados por meio da aplicação de ...

An alternative approach with a low dose and prolonged chemotherapy for palliative treatment of locally advanced, metastatic or recurrent squamous cell head and neck cancer

Appl. cancer res; 37 (), 2017
Background: It is expected that about 65,000 new patients will be diagnosed with head and neck cancer in 2017 in the United States. Patients with recurrent or advanced or metastatic head and neck do not have good survival due to aggressive and recurrent nature of this cancer. Moreover, cumulative and res...

Health-related quality of life of patients with squamous cell carcinoma: a comparison according to tumor location

Abstract: The aim of this study was to evaluate the health-related quality of life (QOL) of patients with squamous cell carcinoma (SCC) according to tumor location. The sample consisted of 27 patients with primary SCC in the oral cavity (n = 15), pharynx (n = 7), and larynx (n = 5) who were undergoing ca...