Kaushik, Dharam;
Boorjian, Stephen A;
Thompson, R. Houston;
Eisenberg, Manuel S;
Carlson, Rachel E;
Bergstralh, Eric J;
Frank, Igor;
Gettman, Matthew T;
Tollefson, Matthew K;
Karnes, R. Jeffrey.
ABSTRACT Objectives: Radical prostatectomy (RP) for locally advanced prostate cancer may reduce the risk of metastasis and cancer-specific death. Herein, we evaluated the outcomes for patients with pT4 disease treated with RP. Materials and methods: Among 19,800 men treated with RP at Mayo Clinic from ...
Biopsia,
Supervivencia sin Enfermedad,
Persona de Mediana Edad,
Análisis Multivariante,
Recurrencia Local de Neoplasia/patología,
Estadificación de Neoplasias,
Antígeno Prostático Específico,
Prostatectomía/estadística & datos numéricos,
Neoplasias de la Próstata/mortalidad,
Neoplasias de la Próstata/patología,
Neoplasias de la Próstata/cirugía,
Estados Unidos/epidemiología
Abstract Introduction: Head and neck cancer represents 3% of all the types of malignant neoplasms and squamous cell carcinoma (SCC) is responsible for 90% of these cases. There have been some studies evaluating the quality of life of these patients, but little is known about the physical and emotional e...
Ramos, Edneia A. S;
Silva, Camila T. da;
Manica, Graciele C. M;
Pereira, Isabela T;
Klassen, Liliane M. B;
Ribeiro, Enilze M. S. F;
Cavalli, Iglenir J;
Braun-Prado, Karin;
Lima, Rubens S;
Urban, Cicero A;
Costa, Fabrício F;
Noronha, Lucia de;
Klassen, Giseli.
Summary Introduction: Breast cancer is the most cause of death, and approximately 90% of these deaths are due to metastases. Matrix metalloproteinase-2 (MMP-2) gelatinase activity is able to degrade a major constituent of the tumor microenvironment, type IV collagen. Two well-established proteins used a...
Biomarcadores de Tumor/análisis,
Brasil/epidemiología,
Neoplasias de la Mama/química,
Neoplasias de la Mama/mortalidad,
Neoplasias de la Mama/patología,
Supervivencia sin Enfermedad,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Metaloproteinasa 2 de la Matriz/análisis,
Persona de Mediana Edad,
Clasificación del Tumor,
Metástasis de la Neoplasia,
Estadificación de Neoplasias,
Pronóstico,
Receptores de Estrógenos/análisis,
Receptores de Progesterona/análisis
Summary Objective: To describe the clinical features, imaging findings and pathological aspects of breast cancer diagnosed in women under the age of 40 years. Method: A retrospective, descriptive study was performed through analysis of medical records between November 2008 and August 2012. One hundred ...
Biopsia,
Brasil,
Neoplasias de la Mama/diagnóstico por imagen,
Neoplasias de la Mama/patología,
Salud de la Familia,
Imagen por Resonancia Magnética,
Mamografía,
Tamizaje Masivo,
Clasificación del Tumor,
Estadificación de Neoplasias,
Estudios Retrospectivos,
Ultrasonografía Mamaria
ABSTRACT Validate the EORTC risk tables in Brazilian patients with NMIBC. Methods: 205 patients were analyzed. The 6 parameters analyzed were: histologic grading, pathologic stage, size and number of tumors, previous recurrence rate and concomitant CIS. The time for first recurrence (TFR), risk score an...
Brasil,
Progresión de la Enfermedad,
Persona de Mediana Edad,
Clasificación del Tumor,
Invasividad Neoplásica,
Recurrencia Local de Neoplasia/patología,
Estadificación de Neoplasias,
Valor Predictivo de las Pruebas,
Estudios Prospectivos,
Reproducibilidad de los Resultados,
Medición de Riesgo/métodos,
Factores de Riesgo,
Factores de Tiempo,
Neoplasias de la Vejiga Urinaria/patología,
Neoplasias de la Vejiga Urinaria/cirugía
ABSTRACT BACKGROUND: Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropriate regimens for these pati...
Antineoplásicos/efectos adversos,
Antineoplásicos/uso terapéutico,
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos,
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/mortalidad,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/mortalidad,
Estadificación de Neoplasias,
Compuestos de Platino/efectos adversos,
Compuestos de Platino/uso terapéutico,
Calidad de Vida,
Ensayos Clínicos Controlados Aleatorios como Asunto
ABSTRACT INTRODUCTION: Treatments used in head and neck cancer greatly impact the physical, psychological and functional state of patients. Evaluation of quality of life has become an integral part of the treatment. OBJECTIVE: This retrospective study evaluates features involved in changes in quality o...
ABSTRACT INTRODUCTION: It is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in groups of low, interm...
Carcinoma de Células Escamosas/patología,
Carcinoma de Células Escamosas/secundario,
Carcinoma de Células Escamosas/cirugía,
Estudios de Casos y Controles,
Ganglios Linfáticos/patología,
Metástasis Linfática,
Neoplasias de la Boca/patología,
Neoplasias de la Boca/cirugía,
Cuello,
Disección del Cuello,
Estadificación de Neoplasias,
Estudios Retrospectivos,
Factores de Riesgo
ABSTRACT INTRODUCTION: Oral squamous cell carcinoma (OSCC) is a serious public health problem, due to its high mortality rate and worldwide rising incidence. OSCC susceptibility is mediated by interactions between genetic and environmental factors. Studies suggest that genetic variants encoding enzymes ...
Carcinoma de Células Escamosas/enzimología,
Carcinoma de Células Escamosas/genética,
Estudios de Casos y Controles,
Cistationina betasintasa/genética,
Predisposición Genética a la Enfermedad/genética,
Genotipo,
Metilenotetrahidrofolato Reductasa (NADPH2)/genética,
Neoplasias de la Boca/enzimología,
Neoplasias de la Boca/genética,
Estadificación de Neoplasias,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Longitud del Fragmento de Restricción,
Pronóstico
