Wang, Changyi;
Xu, Guodong;
Wen, Qi;
Peng, Xiaolin;
Chen, Hongen;
Zhang, Jingwen;
Xu, Shan;
Zhang, Chunhui;
Zhang, Min;
Ma, Jianping;
Hui, Zhaohui;
Wu, Guifu;
Ma, Min.
OBJECTIVES: Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke. The present study was performed to examine the possible effects of Cystathionine β-synthase promoter methylation on the de...
Factores de Edad,
Pueblo Asiatico/genética,
Biomarcadores/metabolismo,
Estudios de Casos y Controles,
Cistationina betasintasa/metabolismo,
Metilación de ADN,
Homocisteína/metabolismo,
Hipertensión/enzimología,
Regiones Promotoras Genéticas,
Medición de Riesgo,
Factores Sexuales,
Accidente Cerebrovascular/enzimología
The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited a...
Biomarcadores/metabolismo,
Salud Materna,
Metabolómica/métodos,
Metabolómica/tendencias,
Atención Perinatal,
Complicaciones del Embarazo/diagnóstico,
Complicaciones del Embarazo/metabolismo,
Tercer Trimestre del Embarazo/metabolismo,
Nacimiento Prematuro/diagnóstico,
Pronóstico,
Investigación Biomédica Traslacional/tendencias
Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in th...
ABSTRACT BACKGROUND: The role of villous atrophy in apoptosis, a distinctive feature of celiac disease, is a matter of controversy. The aim of this study was to determine the apoptosis rate through immunohistochemical staining for M30 and M65 in celiac disease cases. DESIGN AND SETTING: Analytical cr...
Abstract Objective: To demonstrate the underlying mechanisms of aortic dissection compared to those of coronary artery disease in terms of the transforming growth factor-beta (TGF-β) signaling pathway. Methods: Twenty consecutive aortic dissection patients and 20 consecutive coronary artery diseas...
Abstract Introduction: Although the association between diabetes mellitus type 1 (T1DM) and celiac disease (CD) is well established; there are only a few studies that focus on South American children, haplotypes and their possible associations. Objective: To determine the prevalence of CD markers in ...
Enfermedad Celíaca/epidemiología,
Diabetes Mellitus Tipo 1/complicaciones,
Antígenos HLA-DQ/genética,
Alelos,
Biomarcadores/metabolismo,
Enfermedad Celíaca/diagnóstico,
Enfermedad Celíaca/genética,
Colombia/epidemiología,
Diabetes Mellitus Tipo 1/epidemiología,
Diabetes Mellitus Tipo 1/genética,
Cetoacidosis Diabética/epidemiología,
Genotipo,
Prevalencia,
Factores de Tiempo
Abstract Background: Obesity is recognized as a major risk factor for the development of several metabolic complications. However, some obese individuals have a favorable metabolic profile. Objective: The aim of this study was to identify an easy parameter for recognizing metabolically healthy obese (MHO...
Biomarcadores/metabolismo,
Glucemia/análisis,
Índice de Masa Corporal,
Exactitud de los Datos,
Insulina/sangre,
Resistencia a la Insulina,
Grasa Intraabdominal/metabolismo,
Síndrome Metabólico/diagnóstico,
Síndrome Metabólico/metabolismo,
Obesidad/diagnóstico,
Obesidad/metabolismo,
Fenotipo,
Sensibilidad y Especificidad,
Triglicéridos/sangre,
Circunferencia de la Cintura
Abstract Objective: To evaluate the efficacy of natriuretic peptide (NP)-guided therapy compared to clinically-guided therapy in reducing mortality and hospital admissions in chronic heart failure (HF) patients. Methods: Randomised clinical trials (RCT) were selected through a systematic review. Four...
Introducción. La albúmina modificada por la isquemia puede aumentar en el asma (IMA), estrés oxidativo y la inflamación. El objetivo fue evaluar las concentraciones de IMA en niños asmáticos durante períodos asintomáticos y de exacerbación. Población y métodos. Niños asmáticos y sanos en seg...
Antiinflamatorios/administración & dosificación,
Asma/tratamiento farmacológico,
Asma/fisiopatología,
Biomarcadores/metabolismo,
Proteína C-Reactiva/metabolismo,
Albúmina Sérica Humana/metabolismo,
Índice de Severidad de la Enfermedad,
Pruebas Cutáneas/métodos,
Factores de Tiempo,
Estudios Prospectivos,
Proyectos Piloto,
Estudios Transversales,
Estudios de Casos y Controles
Abstract The heat shock proteins are endogenous proteins with the ability to act as molecular chaperones. Methods that provide cell protection by way of some damage can positively influence the results of surgery. The present review summarizes current knowledge concerning the cardioprotective role of the...
