Results: 137

Immunosuppressive mechanism of Hypoderma lineatum secreted serine esterase, a potential modulatory method used to inhibit transplant rejection

Background: Although immunosuppressive therapies have made organ transplantation a common medical procedure worldwide, chronic toxicity has a major issue for long-term treatment. One method to improve therapies and methods is the application of immunomodulatory agents from parasites such as Hypoderma lin...

Os significados atribuídos ao transplante renal
The meaning attributed to kidney transplant

Rev. cuba. enferm; 34 (1), 2018
RESUMO Introdução: Conhecer o significado do transplante renal para as pessoas que o vivenciam pode constituir uma oportunidade em desmistificar conceitos pré-estabelecidos. Objetivo: Apresentar o significado do transplante renal para as pessoas transplantadas. Métodos: Estudo qualitativo, descrit...

Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience

Arq. bras. cardiol; 110 (2), 2018
Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Object...

Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts

Einstein (Säo Paulo); 16 (4), 2018
ABSTRACT Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. Methods: A single-center, retrospective study involving 226 patients submitted to kidne...

Intestinal microbiota changes after solid organ transplantation: a systematic review

Clin. biomed. res; 38 (1), 2018
Introduction: The intestinal microbiota may undergo changes after solid organ transplantation. The purpose of this systematic review was to characterize the intestinal microbiota of patients undergoing solid organ transplantation. Methods: MEDLINE, EMBASE and Cochrane Library databases were searched from...

Evaluación de los resultados del trasplante hepático con hígados que nadie quiere

Rev. Hosp. El Cruce; (21), 2017
INTRODUCCIÓN: La escasez de donantes para suplir la demanda de trasplantes es un problema Mundial. “Hígados que nadie quiere” (HNQ) define injertos que fueron rechazados numerosas veces por varios centros antes de su aceptación. OBJETIVO: evaluar los resultados en la utilización de “HNQ” en ...

Description and evaluation of experimental models for uterine transplantation in pigs

Einstein (Säo Paulo); 15 (4), 2017
ABSTRACT Objective: To evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression. Methods: We included 12 sows, and immunosuppression was performed with minimal doses of cyclosporine, and cross-match was done to exclude the possibility of blood inco...

Evaluation of the predisposition and clinical impact of BK virus replication in kidney transplant patients

An. acad. bras. ciênc; 89 (1,supl), 2017
ABSTRACT The BK virus (BKV) produces a subclinical kidney infection in immunocompetent individuals. However, viremia may occur in kidney transplant patients with ongoing immunosuppression. BKV-associated nephropathy (BKVN) has no specific treatment and is a leading cause of organ transplant loss. In this...

Critical analysis of graft loss and death in kidney transplant recipients treated with mTOR inhibitors

J. bras. nefrol; 39 (1), 2017
Abstract Registry studies and systematic reviews have shown higher risk for mortality and graft loss in patients in use of mTOR inhibitors (mTORi) compared to calcineurin-based (CNI) immunosuppressive regimens. The majority of these studies pooled data from early trials using different strategies such as...

Conversion to Mycophenolate Mofetil Monotherapy in Liver Recipients: Calcineurin Inhibitor Levels are Key

Ann. hepatol; 16 (1), 2017
Abstract: The use of calcineurin inhibitors (CNI) after liver transplantation is associated with post-transplant nephrotoxicity. Conversion to mycophenolate mofetil (MMF) monotherapy improves renal function, but is related to graft rejection in some recipients. Our aim was to identify variables associate...