Autism spectrum disorders (ASDs) are characterized by deficits in the individual’s ability to socialize, communicate, and use the imagination, in addition to stereotyped behaviors. These disorders have a heterogenous phenotype, both in relation to symptoms and regarding severity. Organic problems r...
Trastorno del Espectro Autista/etiología,
Trastorno del Espectro Autista/metabolismo,
Trastorno del Espectro Autista/fisiopatología,
Enfermedades Gastrointestinales/metabolismo,
Enfermedades Gastrointestinales/fisiopatología,
Microbioma Gastrointestinal,
Tracto Gastrointestinal/metabolismo,
Tracto Gastrointestinal/microbiología,
Tracto Gastrointestinal/fisiopatología,
Péptidos Opioides/efectos adversos,
Péptidos Opioides/análisis,
Péptidos Opioides/metabolismo,
Estrés Oxidativo,
Compuestos de Sulfhidrilo/metabolismo
ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species ...
ABSTRACT PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Ti...
Acetatos/farmacología,
Antioxidantes/farmacología,
Ovario/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Dibenzodioxinas Policloradas/toxicidad,
Quinolinas/farmacología,
Catalasa/metabolismo,
Glutatión/metabolismo,
Folículo Ovárico/efectos de los fármacos,
Ovario/patología,
Distribución Aleatoria,
Ratas Wistar,
Superóxido Dismutasa/metabolismo,
Útero/patología
ABSTRACT PURPOSE: To evaluated the long-term effect of scopolamine and sesame oil on spatial memory. METHODS: Memory impairment induced by Intracerebroventricular (ICV) injection of scopolamine hydrochloride (10 μg/ rat). Animals were gavaged for 4 weeks with saline, sesame oil (0.5, 1, or 2 mL/k...
Adyuvantes Anestésicos/efectos adversos,
Amnesia/tratamiento farmacológico,
Antioxidantes/administración & dosificación,
Escopolamina/efectos adversos,
Aceite de Sésamo/administración & dosificación,
Enfermedad de Alzheimer/prevención & control,
Amnesia/inducido químicamente,
Antioxidantes/química,
Modelos Animales de Enfermedad,
Compuestos Férricos/química,
Glutatión Peroxidasa/química,
Inyecciones Intraventriculares,
Aprendizaje por Laberinto,
Memoria/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Superóxido Dismutasa/química
Abstract Objective To determine eight parameters of oxidative stress markers in erythrocytes from children with sickle cell disease and compare with the same parameters in erythrocytes from healthy children, since oxidative stress plays an important role in the pathophysiology of sickle cell disease and...
Anemia de Células Falciformes/sangre,
Anemia de Células Falciformes/fisiopatología,
Biomarcadores/sangre,
Estudios de Casos y Controles,
Catalasa/sangre,
Eritrocitos/metabolismo,
Glucosafosfato Deshidrogenasa/sangre,
Glutatión/sangre,
Hemólisis/fisiología,
Metahemoglobina/análisis,
Estrés Oxidativo/fisiología,
Especies Reactivas de Oxígeno/sangre,
Valores de Referencia,
Estadísticas no Paramétricas,
Superóxido Dismutasa/sangre
ABSTRACT Objective The objective of this study, in addition to confirming that therapy with 131I causes oxidative stress, was to evaluate the effect of supplementation with vitamins C and E and selenium on this phenomenon by measuring plasma 8-epi-PGF2a, a marker of lipid peroxidation. Subjects and met...
Análisis de Varianza,
Antioxidantes/uso terapéutico,
Ácido Ascórbico/uso terapéutico,
Carcinoma/tratamiento farmacológico,
Carcinoma/metabolismo,
Carcinoma/radioterapia,
Carcinoma/cirugía,
Suplementos Dietéticos,
Dinoprost/análogos & derivados,
Dinoprost/sangre,
Radioisótopos de Yodo/efectos adversos,
Peroxidación de Lípido/efectos de la radiación,
Estrés Oxidativo/efectos de la radiación,
Estudios Prospectivos,
Reproducibilidad de los Resultados,
Neoplasias de la Tiroides/radioterapia,
Resultado del Tratamiento,
Factores de Tiempo
ABSTRACT Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Gr...
Antioxidantes/análisis,
Antioxidantes/metabolismo,
Catarata/etiología,
Catarata/metabolismo,
Diabetes Mellitus Experimental/metabolismo,
Glucocorticoides/farmacología,
Cristalino/metabolismo,
Menopausia/metabolismo,
Metilprednisolona/farmacología,
Modelos Animales,
Ovariectomía,
Oxidantes/metabolismo,
Estrés Oxidativo/fisiología,
Ratas Wistar,
Valores de Referencia,
Espectrofotometría
Laminitis in horses can be associated with lesions in multiple organs secondary to sepsis. Twenty-one horses suffering from gastrointestinal disorders were used in the experiment; 7 horses with experimentally induced endotoxemia and intestinal ischaemia, and 14 horses suffering from naturally occurring c...
Caballos/lesiones,
Pezuñas y Garras/lesiones,
Pezuñas y Garras/patología,
Estrés Oxidativo,
Endotoxemia/veterinaria,
Isquemia/veterinaria,
Sepsis/veterinaria,
Enfermedades Gastrointestinales/veterinaria,
Cólico/veterinaria,
Ácido Peroxinitroso,
Superóxido Dismutasa
Introduction: Preeclampsia is the leading cause of maternal and perinatal mortality and morbidity. Several studies have associated oxidative stress with the etiopathogenesis of preeclampsia but there is little evidence to link this with the appearance and severity of complications. Objective: In this stu...
Objetivou-se avaliar o efeito da adição de diferentes concentrações de melatonina no sêmen diluído de carneiros após criopreservação. Foram coletados 10 ejaculados de três carneiros adultos (n=30), por meio de vagina artificial para ovinos. Os ejaculados coletados foram diluídos em Tris-Gema d...
