A doxorrubicina (DOX) é um quimioterápico utilizado no tratamento de neoplasias malignas, porém possui a cardiotoxicidade como efeito colateral. O objetivo deste trabalho foi verificar quanto à ação do extrato etanólico da casca do pequi (Caryocar brasiliense) (EECP) por meio de avaliação morfol...
Lima, Sonia Oliveira;
Figueiredo, Maria Bernadete Galrão de Almeida;
Santana, Vanessa Rocha de;
Santana, Danillo Primo Andrade;
Nogueira, Matheus de Souza;
Porto, Erick Sobral;
Andrade, Renata Lima Batalha de;
Santos, Jessica Macêdo;
Albuquerque Junior, Ricardo Luiz Cavalcanti de;
Cardoso, Juliana Cordeiro.
Abstract Purpose: To evaluate the effect of aqueous extract of Baccharis trimera leaves on the proliferative capacity of the liver after partial hepatectomy (PH) in rats. Methods: Twenty Wistar rats weighing between 300 and 450g were divided into two groups: control (HP) and test (HP100-rats that recei...
ladonia substellata Vainio is a lichen found in different regions of the world, including the Northeast of Brazil. It contains several secondary metabolites with biological activity, including usnic acid, which has exhibited a wide range of biological activities. The aim of this study was to evaluate the...
Cannabis sativa (marihuana) is considered an illicit drug due to its psychoactive properties. Recently, the Chilean government opened to the use cannabis in the symptomatic treatment of some patients. The biological effects of cannabis render it useful for the complementary treatment of specific clinical...
Non-alcoholic fatty liver induces many complications to the liver tissue and also serum related parameters. Medicinal plants are the safe therapeutic strategy for the treatment of diseases. In this regards, the present study was conducted to evaluate the effect of Tribulus terrestris (T. terrestris) extr...
ABSTRACT Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes w...
Bauhinia/química,
Glucemia/análisis,
Glucemia/efectos de los fármacos,
Peso Corporal,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Ingestión de Líquidos,
Ingestión de Alimentos,
Prueba de Tolerancia a la Glucosa,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Hojas de la Planta/química,
Ratas Wistar,
Reproducibilidad de los Resultados,
Estreptozocina,
Factores de Tiempo,
Resultado del Tratamiento
ABSTRACT INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of vari...
Antiprotozoarios/farmacología,
Antiprotozoarios/uso terapéutico,
Artemisia annua/química,
Cricetinae,
Leishmania/efectos de los fármacos,
Leishmaniasis Cutánea/tratamiento farmacológico,
Pruebas de Sensibilidad Parasitaria,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Hojas de la Planta/química,
Resultado del Tratamiento
Ju, J;
Chen, W;
Lai, Y;
Wang, L;
Wang, H;
Chen, WJ;
Zhao, X;
Ye, H;
LI, Y;
Zhang, Y.
Oxidative stress plays an important role in the development of diabetic cardiomyopathy. In the present study, we determined whether the effect of astragalus polysaccharides (APS) on diabetic cardiomyopathy was associated with its impact on oxidative stress. Streptozotocin (STZ)-induced diabetic mice and ...
Apoptosis/efectos de los fármacos,
Planta del Astrágalo/química,
Proliferación Celular/efectos de los fármacos,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Cardiomiopatías Diabéticas/tratamiento farmacológico,
Cardiomiopatías Diabéticas/patología,
Ratones Endogámicos C57BL,
Ratones Noqueados,
Microscopía Electrónica de Transmisión,
Miocitos Cardíacos/efectos de los fármacos,
Miocitos Cardíacos/ultraestructura,
Estrés Oxidativo/efectos de los fármacos,
Extractos Vegetales/uso terapéutico,
Polisacáridos/uso terapéutico,
Estreptozocina,
Superóxido Dismutasa/genética
Abstract The purpose of this study is to evaluate the effect of the avocado/soybean unsaponifiables (ASU) on the treatment of induced periodontitis in rats. Periodontitis was induced in 84 rats via ligature placement around the second upper molar, which was removed after 7 days, and scaling and root plan...
Expresión Génica,
Inmunohistoquímica,
Interleucina-1beta/análisis,
Interleucina-6/análisis,
Periodontitis/tratamiento farmacológico,
Periodontitis/etiología,
Periodontitis/patología,
Persea/química,
Extractos Vegetales/uso terapéutico,
Ligando RANK/análisis,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Reproducibilidad de los Resultados,
Aplanamiento de la Raíz/métodos,
Glycine max/química,
Fosfatasa Ácida Tartratorresistente/análisis,
Factores de Tiempo,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/análisis
Objetivo: Evaluar el efecto del extracto acuoso de Tropaeolum tuberosum “mashua” sobre el deterioro de la memoria y la lipoperoxidación inducida por fluoxetina en hígado en Rattus rattus var. albinus ooferectomizadas. Materiales y métodos: Estudio experimental. Se usaron 29 animales de experimenta...
