Results: 174

Reactivation of Chagas disease in a heart transplant patient infected by sylvatic trypanosoma cruzi discrete typing unit I

Abstract Heart transplantation is an effective treatment for Chagas disease patients with severe cardiomyopathy. However, Trypanosoma cruzi reactivation is of great concern. The T. cruzi parasite is classified into six discrete typing units (DTUs identified as TcI-TcVI). It is unknown whether there is an...

Serum Levels of Infliximab and Anti-Infliximab Antibodies in Brazilian Patients with Crohn's Disease

Clinics; 74 (), 2019
OBJECTIVES: The aim of this study was to evaluate the quantitative serum level of infliximab (IFX) as well as the detection of anti-infliximab antibodies (ATIs) in patients with Crohn's disease (CD). METHOD: Forty patients with CD under treatment at a tertiary center in southeastern Brazil were evaluate...

Diagnosis and treatment of latent tuberculosis infection in patients undergoing treatment with immunobiologic agents: a four-year experience in an endemic area

J. bras. pneumol; 45 (6), 2019
ABSTRACT Objective: To describe the incidence of active tuberculosis and the occurrence of adverse events after isoniazid treatment in patients with latent tuberculosis infection (LTBI) who also had chronic inflammatory diseases and were treated with immunobiologic agents in an endemic area in Brazil. ...

Guidelines of the Brazilian Society of Rheumatology for the treatment of systemic autoimmune myopathies

Adv Rheumatol; 59 (), 2019
Abstract Background: Recommendations of the Myopathy Committee of the Brazilian Society of Rheumatology for the management and therapy of systemic autoimmune myopathies (SAM). Main body: The review of the literature was done in the search for the Medline (PubMed), Embase and Cochrane databases includin...

Síndrome POEMS: um diagnóstico desafiador

A síndrome POEMS é um distúrbio multissistêmico. Sua patogênese não está totalmente estabelecida, mas sabe-se que tem relação com fator de crescimento vascular endotelial, interleucinas e fator de necrose tumoral alfa. A idade média de incidência é 50 anos, com maior prevalência em homens. N...

Effects of combined oral doxycycline and topical cyclosporine treatment on ocular signs, symptoms, and tear film parameters in rosacea patients

Arq. bras. oftalmol; 81 (6), 2018
ABSTRACT Purpose: This study reports the effects of combined use of oral doxycycline and topical cyclosporine on ocular signs, symptoms, and tear film parameters in rosacea patients. Methods: Fifty-four right eyes of 54 patients were included in this study. All patients underwent full ophthalmologic ex...

Multiple sclerosis: disease modifying therapy and the human leukocyte antigen

Arq. neuropsiquiatr; 76 (10), 2018
ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginni...

Pénfigo vulgar en pediatría a propósito de un caso

Rev. chil. pediatr; 89 (5), 2018
Resumen: Introducción: El pénfigo vulgar es una enfermedad grave y poco frecuente en niños. Su diagnóstico y tratamiento oportuno permite modificar el pronóstico. El objetivo es describir las características clínicas y el abordaje diagnóstico y terapéutico de esta poco frecuente enfermedad ves...

Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis

Arq. neuropsiquiatr; 76 (8), 2018
ABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Res...

Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico

Rev. méd. Chile; 146 (7), 2018
Paraquat, a non-selective bipyridyl pesticide, is one of the leading causes of death from intoxication in many parts of Asia and America. It is the second most sold herbicide worldwide, being widely used in Chile. Its ingestion generates toxicity due to the release of superoxide radicals, mainly affectin...