Okada, Mieko;
Falcão, Luiz Fernando Reis;
Ferez, David;
Martins, José Luiz;
Errante, Paolo Ruggero;
Rodrigues, Francisco Sandro Menezes;
Caricati-Neto, Afonso;
Marinho, Márcia;
Fenelon, Guilherme;
Oliveira-Júnior, Itamar Souza.
Abstract Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+...
Antihipertensivos/farmacología,
Atenolol/farmacología,
Corazón/efectos de los fármacos,
Intestinos/irrigación sanguínea,
Daño por Reperfusión/patología,
Antihipertensivos/farmacocinética,
Antihipertensivos/uso terapéutico,
Atenolol/uso terapéutico,
Enfermedades Cardiovasculares/prevención & control,
Arteria Mesentérica Superior,
Ratas Wistar
Abstract Purpose: To investigate the expression of nitric oxide synthase (NOS) and apoptosis associated with ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal ischemia (I) and reperfusion (R) injury. Methods: Thirty male rats were assigned to 5 groups: (CG), no clamping of the sup...
Apoptosis/efectos de los fármacos,
Enfermedades Intestinales/prevención & control,
Intestinos/irrigación sanguínea,
Precondicionamiento Isquémico,
Óxido Nítrico Sintasa/metabolismo,
Pentoxifilina/uso terapéutico,
Apoptosis/fisiología,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Enfermedades Intestinales/enzimología,
Intestinos/patología,
ARN Mensajero/análisis,
Ratas Wistar,
Vasodilatadores/uso terapéutico
Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All...
Riñón/efectos de los fármacos,
Riñón/patología,
Daño por Reperfusión/prevención & control,
Tadalafilo/uso terapéutico,
Vasodilatadores/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Riñón/irrigación sanguínea,
Distribución Aleatoria,
Ratas Wistar,
Daño por Reperfusión/tratamiento farmacológico,
Daño por Reperfusión/patología,
Tadalafilo/farmacología,
Factores de Tiempo,
Vasodilatadores/farmacología
Abstract Background: Different types of high-fat and/or high-energy diets have been used to induce obesity in rodents. However, few studies have reported on the effects observed at the initial stage of obesity induced by high-fat feeding on cardiac functional and structural remodelling. Objective: To c...
Presión Sanguínea,
Western Blotting,
Calcio/metabolismo,
Dieta Alta en Grasa,
Modelos Animales de Enfermedad,
Resistencia a la Insulina,
Obesidad/etiología,
Obesidad/metabolismo,
Obesidad/patología,
Obesidad/fisiopatología,
Músculos Papilares/metabolismo,
Músculos Papilares/patología,
Músculos Papilares/fisiopatología,
Distribución Aleatoria,
Ratas Wistar,
Conducta Sedentaria
Orofacial neuropathic chronic pain (NCP) is frequently attributed to lesions caused by orofacial surgeries and dental treatments. there are many experimental models available to study orofacial NCP, however, many are extremely painful for the animal due to the amplitude of the innervated region. a previo...
Abstract Purpose: To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity. Methods: Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: ...
Abstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assi...
Modelos Animales de Enfermedad,
Hipotermia Inducida/métodos,
Precondicionamiento Isquémico/métodos,
Riñón/irrigación sanguínea,
Riñón/química,
Riñón/patología,
Peroxidación de Lípido,
Nefrectomía,
Distribución Aleatoria,
Ratas Wistar,
Daño por Reperfusión/sangre,
Daño por Reperfusión/patología,
Daño por Reperfusión/prevención & control
Abstract Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. Methods: Seventy-two Wistar rats were divided into six subgroups of 12 rats, which underwent right orchiectomy at 3, 6, 9, 12, 18, and 24 mont...
Abstract Purpose: To present an alternative experimental model of third degree burn of easy reproducibility. Methods: Eighteen male Wister rats were randomly divided into three groups, 6 of which were allocated to each group. A soldering iron coupled to an aluminum plate was used to produce burn, at a ...
Abstract Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane onl...
Lesión Renal Aguda/sangre,
Lesión Renal Aguda/inducido químicamente,
Lesión Renal Aguda/prevención & control,
Anestesia General/efectos adversos,
Anestésicos por Inhalación/farmacología,
Ácido Ascórbico/farmacología,
Biomarcadores/sangre,
Modelos Animales de Enfermedad,
Éteres Metílicos/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Sevoflurano,
Vitaminas/farmacología
