Goudouris, Ekaterini Simões;
Silva, Almerinda Maria do Rego;
Ouricuri, Aluce Loureiro;
Grumach, Anete Sevciovic;
Condino-Neto, Antonio;
Costa-Carvalho, Beatriz Tavares;
Prando, Carolina Cardoso de Mello;
Kokron, Cristina Maria;
Vasconcelos, Dewton de Moraes;
Tavares, Fabíola Scancetti;
Segundo, Gesmar Rodrigues Silva;
Barreto, Irma Cecília Douglas Paes;
Dorna, Mayra de Barros;
Barros, Myrthes Anna Maragna Toledo;
Forte, Wilma Carvalho Neves.
ABSTRACT In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary i...
Abstract:The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hem...
Antivenenos/inmunología,
Antivenenos/farmacología,
Bothrops,
Venenos de Crotálidos/inmunología,
Venenos de Crotálidos/toxicidad,
Evaluación Preclínica de Medicamentos,
Factores Inmunológicos/inmunología,
Factores Inmunológicos/farmacología,
México,
Pruebas de Neutralización,
Reproducibilidad de los Resultados,
Mordeduras de Serpientes/tratamiento farmacológico
Abstract To determine the association between factors and adherence to immunomodulator treatment in people with multiple sclerosis treated in reference centers. Cross-sectional study conducted with 188 people who used immunomodulators in three reference centers in Ceará from March to July 2012. Adherenc...
Generar recomendaciones informadas en la evidencia para el tratamiento de los pacientes con enfermedad de Crohn. Apoyar al tratamiento oportuno y seguro de los pacientes de enfermedad de Crohn considerando las minimización de secuelas y la hospitalización. Apoyar a los tomadores de decisiones a formula...
Abstract Background: Post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized. Objective: To describe the clinical response, overall and graft survival of patients in our center with this complication after kidney tran...
Trasplante de Riñón/Métodos,
Trastornos Linfoproliferativos/tratamiento farmacológico,
Rituximab/uso terapéutico,
Serina-Treonina Quinasas TOR/antagonistas & inhibidores,
Estudios de Seguimiento,
Supervivencia de Injerto/efectos de los fármacos,
Factores Inmunológicos/uso terapéutico,
Inmunosupresores/uso terapéutico,
Trastornos Linfoproliferativos/etiología,
Estudios Retrospectivos,
Tasa de Supervivencia,
Resultado del Tratamiento
ABSTRACT A question is raised about an increased risk of severe infection from the use of biological drugs in patients with rheumatoid arthritis. This systematic review of observational studies aimed at assessing the risk of severe infection associated with the use of anakinra, rituximab, and abatacept i...
Abstract Systemic sclerosis (SSc) is a chronic autoimmune disease with a high morbidity and mortality. Although cyclophosphamide is effective for severe and refractory cases, there is demand for new treatments. The biological treatment with B-cell depletion with rituximab (RTX) has demonstrated efficacy ...
ABSTRACT The authors present a case of necrotizing scleritis after pterygium excision successfully treated with rituximab after attempts with high doses of corticosteroids and immunosuppressive drugs. A literature review revealed case reports and a phase I/II dose-ranging randomized clinical trial using ...
Factores Inmunológicos/uso terapéutico,
Procedimientos Quirúrgicos Oftalmológicos/efectos adversos,
Complicaciones Posoperatorias/tratamiento farmacológico,
Complicaciones Posoperatorias/etiología,
Pterigion/cirugía,
Reproducibilidad de los Resultados,
Rituximab/uso terapéutico,
Esclerótica/efectos de los fármacos,
Esclerótica/patología,
Escleritis/tratamiento farmacológico,
Escleritis/etiología,
Resultado del Tratamiento
Contexto: A esclerose múltipla (EM) é uma condição inflamatória desmielinizante, de origem autoimune que acomete prejuízos na condução do impulso elétrico no sistema nervoso central (SNC). De caráter progressivamente incapacitante, afeta aspectos físicos, psicossociais e econômicos não só d...
Hydroxychloroquine (HCQ) is by far the most frequently used antimalarial for the management of Systemic Autoimmune Diseases. It has immunomodulatory, hypolipidemic, hypoglycemic and antithrombotic properties and it diminishes the risk of malignancies. The most important mechanisms to explain the immunomo...
