Abstract Purpose: To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hou...
Nicodemo, Mariana de Castro;
Neves, Lia Renó das;
Aguiar, Josafá Carvalho;
Brito, Flaviane de Souza;
Ferreira, Isabelle;
Sant'Anna, Luciana Barros;
Raniero, Leandro José;
Martins, Rodrigo Álvaro Lopes;
Barja, Paulo Roxo;
Arisawa, Emilia Angela Lo Schiavo.
Abstract Purpose: To evaluate the effect of human amniotic membrane (hAM) fragment on inflammatory response, proliferation of fibroblast and organization of collagen fibers in injured tendon. Methods: Sixty rats were divided into 3 groups: C - surgical procedures without tendon lesion and with simula...
Tendón Calcáneo/lesiones,
Amnios/trasplante,
Traumatismos de los Tendones/cirugía,
Cicatrización de Heridas,
Tendón Calcáneo/patología,
Colágeno/fisiología,
Modelos Animales,
Ratas Wistar,
Rotura/patología,
Rotura/cirugía,
Espectroscopía Infrarroja por Transformada de Fourier,
Traumatismos de los Tendones/patología,
Factores de Tiempo
Abstract Purpose: To investigate the effect of buserelin on gonadal structure and function in adult male rats. Methods: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µ...
Apoptosis/efectos de los fármacos,
Buserelina/administración & dosificación,
Fármacos para la Fertilidad Masculina/administración & dosificación,
Túbulos Seminíferos/efectos de los fármacos,
Buserelina/efectos adversos,
Fármacos para la Fertilidad Masculina/efectos adversos,
Etiquetado Corte-Fin in Situ,
Modelos Animales,
Ratas Wistar,
Túbulos Seminíferos/patología,
Testículo/anatomía & histología,
Testículo/efectos de los fármacos,
Testosterona/sangre
Abstract Purpose: To compare the polypropylene mesh (Marlex®) to Vicryl®, Parietex composite® and Ultrapro® meshes to assess the occurrence of adhesions in the intraperitoneal implantation. Methods: Sixty Wistar rats were allocated into three groups: PP+V, in which all the animals received a poly...
Colágeno,
Hernia Ventral/cirugía,
Poliésteres,
Poliglactina 910,
Polipropilenos,
Mallas Quirúrgicas,
Adherencias Tisulares/prevención & control,
Pared Abdominal/cirugía,
Materiales Biocompatibles,
Modelos Animales,
Prótesis e Implantes,
Distribución Aleatoria,
Ratas Wistar
Abstract Purpose To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimen...
Materiales Biocompatibles/uso terapéutico,
Regeneración Ósea,
Aceite de Ricino/química,
Durapatita/uso terapéutico,
Fémur,
Fijación Interna de Fracturas/métodos,
Vidrio/química,
Durapatita/química,
Materiales Biocompatibles/química,
Fijadores Internos,
Modelos Animales,
Distribución Aleatoria,
Ratas Wistar
Fundamento: O treinamento resistido promove benefícios à saúde cardiovascular, a qual é influenciada pela privação de sono. Objetivo: Investigar o efeito prévio do treinamento resistido de alta intensidade sobre a contratilidade miocárdica de ratos privados de sono paradoxal. Métodos: Quarenta r...
Entrenamiento de Fuerza/métodos,
Privación de Sueño/complicaciones,
Contracción Miocárdica,
Enfermedades Cardiovasculares/diagnóstico,
Enfermedades Cardiovasculares/complicaciones,
Ratas Wistar,
Muestreo,
Modelos Animales,
28599,
Análisis de Varianza,
Músculos Papilares
ABSTRACT Purpose: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats. Methods: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of ...
Antioxidantes/administración & dosificación,
Modelos Animales de Enfermedad,
Fluoresceína,
Radioisótopos de Yodo/efectos adversos,
Aparato Lagrimal/efectos de los fármacos,
Aparato Lagrimal/patología,
Aparato Lagrimal/efectos de la radiación,
Traumatismos Experimentales por Radiación/prevención & control,
Protectores contra Radiación/administración & dosificación,
Ratas Wistar,
Lágrimas/fisiología,
Sulfato de Zinc/administración & dosificación
Abstract Background: Radionuclide ventriculography (RV) is a validated method to evaluate the left ventricular systolic function (LVSF) in small rodents. However, no prior study has compared the results of RV with those obtained by other imaging methods in this context. Objectives: To compare the resul...
Antibióticos Antineoplásicos,
Cardiotoxicidad/diagnóstico por imagen,
Modelos Animales de Enfermedad,
Doxorrubicina,
Ecocardiografía,
Fibrosis,
Ventriculografía con Radionúclidos,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Estadísticas no Paramétricas,
Disfunción Ventricular Izquierda/inducido químicamente,
Disfunción Ventricular Izquierda/diagnóstico por imagen,
Disfunción Ventricular Izquierda/patología,
Función Ventricular Izquierda/efectos de los fármacos
ABSTRACT Alcohol consumption aggravates injuries caused by ischemia. Many molecular mechanisms are involved in the pathophysiology of cerebral ischemia, including neurotransmitter expression, which is regulated by microRNAs. Objective: To evaluate the microRNA-219 and NMDA expression in brain tissue and...
Abstract Purpose: To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and...
Claudina-3/análisis,
Colon/química,
Curcuma/química,
Enema/métodos,
Mucosa Intestinal/química,
Ocludina/análisis,
Aceites de Plantas/farmacología,
Colon/efectos de los fármacos,
Colon/patología,
Colostomía,
Heces,
Inmunohistoquímica,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Ratas Wistar
