Results: 8

Pre-treatment of the beta3-adrenergic receptor agonist BRL37344 reduces in vivo myocardial ischemia/reperfusion injury by improving AMPK and SIRT1 activity and by suppressing mTOR and p70S6K signaling pathways

Abstract This study aimed to investigate the role and signaling pathways of β3-AR in myocardial ischemia/reperfusion (I/R) injury, which is one of the leading causes of death worldwide. 47 male rats were randomly divided into two main groups to evaluate infarct size and molecular parameters. Rats in...

Bexiga hiperativa
Overactive bladder

Femina; 46 (6), 2018

Effect of constant light and immobilization stress on rat submandibular saliva secretory response induced by cholinergic and peptidergic agonists

J. oral res. (Impresa); 7 (1), 2018
The aim of this work was to analyse the parasympathetic control of submandibular saliva secretory response to cholinergic and peptidergic agonists in rats chronically exposed to constant light or repeated immobilization. Thirty two adult male Wistar rats were used: LL (8 rats exposed to constant light fo...

Diagnosis and treatment of anaphylaxis: there is an urgent needs to implement the use of guidelines

Einstein (Säo Paulo); 15 (4), 2017
ABSTRACT Anaphylaxis is a severe, life-threatening generalized or systemic hypersensitivity reaction that requires rapid and adequate care. This study aimed to obtain an integrated view of the level of physicians' knowledge related with treatment of anaphylaxis in studies published within the last 5 year...

Cardiopulmonary resuscitation in an average brazilian intensive care unit: should we perform less or better?

Abstract Introduction: Few data can be found about cardiac arrest in the intensive care unit outside reference centers in third world countries. Objective: To study epidemiology and prognostic factors associated with cardiac arrest in the intensive care unit (ICU) in an average Brazilian center. Metho...

Cocaine long-term administration induces myocardial depressant effects and adrenoceptors desensitization

Acta cient. venez; 53 (3), 2002
Cocaine as a drug of abuse can cause many cardiovascular toxic effects. The objective of this work was to study the mechanism of the negative inotropic effect of cocaine on isolated right ventricle strips and its relationship with myocardial catecholamines desensitization after long- term cocaine adminis...

Etiopatogenia da microangiopatia renal no diabetes mellitus.
Pathogenesis of renal microangiopathy in diabetes mellitus

A autora faz uma abordagem da literatura pertinente aos mecanismos geradores da microangiopatia diabetica, focalizando sobretudo a nefropatia e seus aspectos bioquimico-estruturais, no sentido de correlacionar alteracoes de membranas e sensibilidade de receptores. Apresentam tambem um enfoque sobre o con...