El alelo HLA B*57:01 es un marcador genético asociado con la hipersensibilidad al fármaco anti-retroviral abacavir (ABC) y su frecuencia en la población peruana todavía es desconocida. El objetivo fue identificar el alelo HLA B*57:01 en una población militar de Lima, Perú. Se reclutaron 43 personas...
Fármacos Anti-VIH/efectos adversos,
Hipersensibilidad a las Drogas/genética,
Ciclopropanos/efectos adversos,
VIH/genética,
Carga Viral/genética,
Marcadores Genéticos,
Personal Militar,
Recuento de Linfocito CD4,
Hipersensibilidad a las Drogas/inmunología,
Perú,
Infecciones por VIH/genética,
Infecciones por VIH/tratamiento farmacológico,
Antígenos HLA-B/genética,
Alelos,
Genotipo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Predisposición Genética a la Enfermedad
Abstract Plasmodium falciparum resistance to Chloroquine (CQ) is a significant cause of mortality and morbidity worldwide. There is a paucity of documented data on the prevalence of CQ-resistant mutant haplotypes of Pfcrt and Pfmdr1 genes from malaria-endemic war effected Federally Administered Tribal Ar...
Abstract Genetic variability in the host metabolism of antimalarial drugs influenced by the polymorphisms of cytochrome P450 (CYP) could lead to significant changes in antimalarial treatment response. However, little is known about the frequency of alleles CYP2B6, CYP2C8, and CYP2D6 in an Amazonian popul...
ABSTRACT. Monoamine oxidase A (MAOA) polymorphisms have been associated with antisocial disorders. Less attention has been paid to the cognitive functioning of individuals with different MAOA alleles. No study has described the cognitive phenotype associated with the less frequent, low enzyme activity al...
INTRODUCTION: The causal mechanisms behind crack/cocaine use are still unknown, but genetic influences are suggested. OBJECTIVE: To investigate the relationship between the genetic polymorphism TaqI (rs1800497) in the dopamine D2 receptor (DRD2) gene and susceptibility to crack/cocaine dependence in a gr...
INTRODUCTION: The frequency of the premutation alleles of the FMR1 gene varies from 1:100 to 1:260 Israeli, Canadian, Finnish and American women, but it is unknown in Brazil. Premutation carriers may have reduced reproductive age and are at risk of transmitting the expanded allele to their offspring, and...
ABSTRACT Objective: The AKR1B1 gene encodes an enzyme that catalyzes the reduction of glucose into sorbitol. Chronic hyperglycemia in patients with diabetes mellitus (DM) leads to increased AKR1B1 affinity for glucose and, consequently, sorbitol accumulation. Elevated sorbitol increases oxidative stress...
Aldehído Reductasa/genética,
Alelos,
Estudios de Casos y Controles,
Diabetes Mellitus Tipo 2/complicaciones,
Diabetes Mellitus Tipo 2/genética,
Nefropatías Diabéticas/complicaciones,
Nefropatías Diabéticas/genética,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Polimorfismo de Nucleótido Simple
Noro, Fabio;
Alves-Leon, Soniza Vieira;
Fontes-Dantas, Fabricia Lima;
Valle Bahia, Paulo Roberto;
Andreiuolo, Rodrigo Ferrone;
Rueda Lopes, Fernanda Cristina;
Pereira, Valeria Coelho Santa Rita;
Abi-Haila, Livia de Almeida Afonso;
Coutinho, Renan Amaral;
Araujo, Amanda Dutra de;
Marchiori, Edson.
ABSTRACT Background: The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01. Objective: To identify associations between findings in magnetic resonance imaging (MRI) and genetic features in a Brazilian cohort of patients with MS. Methods: We retros...
Alelos,
Frecuencia de los Genes,
Genes MHC Clase II,
Predisposición Genética a la Enfermedad,
Cadenas alfa de HLA-DQ/genética,
Cadenas beta de HLA-DQ,
Cadenas HLA-DRB1/genética,
Imagen por Resonancia Magnética,
Esclerosis Múltiple/diagnóstico por imagen,
Esclerosis Múltiple/genética,
Estudios Retrospectivos
ABSTRACT Objective: The aim of this study was to evaluate the serum activity of PON1 in women according to SNPs L55M and T-107C and diet composition. Materials and methods: Blood and serum samples from 26 women were used. DNA extraction, PCR and digestion with restriction enzymes of the PCR fragment we...
RESUMEN Los polimorfismos genéticos asociados con las caseínas de la leche son de gran importancia, ya que pueden ser usados como marcadores genéticos para mejorar el rendimiento productivo en los hatos lecheros. El objetivo de este estudio fue evaluar la diversidad y estructura genética de 5 SNP de ...
Caseínas,
Leche,
Marcadores Genéticos,
Alelos,
Análisis de Varianza,
Densidad de Población,
Arum maculatum,
Estructuras Genéticas,
Genética,
Nucleótidos,
Polimorfismo Genético,
Variación Genética,
Colombia
