Abstract The goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In this sense, we designed a fatty acid-mimetic substructure including an amide moiety that, among other properties, ...
Resumen La "dermatitis por Paederus", es una dermatitis vesicante secundaria al contacto con coleópteros de este género. Se describen más de 600 especies de Paederus, con predominio en áreas tropicales y subtropicales, varias de ellas se asocian a dermatitis. Al ser apretado o aplastado contra la pie...
ABSTRACT BACKGROUND: Favipiravir is generally used in treating coronavirus disease 2019 (COVID-19) pneumonia in Turkey. OBJECTIVE: To determine the side effects of favipiravir and whether it is a good treatment option. DESIGN AND SETTING: Retrospective study conducted in Atatürk Chest Diseases and Ch...
Abstract A series of Trolox amide derivatives were synthesized by modifying the carboxyl groups of Trolox. Thirty target compounds were obtained and characterized through nuclear magnetic resonance and mass spectrometry. Trolox derivatives were employed to explore the potential structure-antioxidant act...
Abstract In order to overcome the challenges of discovering new antiprotozoal drugs, we synthesized a new class of hybrids based on S-allylCysteine Ester/Caffeic Acid Amide and evaluated four of them against Trypanosoma cruzi and Plasmodium falciparum. Hybrid 6 exhibited good activity on T. cruzi with an...
Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) ...
Amidas/administración & dosificación,
Angiotensina II/farmacología,
Apoptosis/efectos de los fármacos,
Western Blotting,
Cardiomegalia/inducido químicamente,
Cardiomegalia/metabolismo,
Cardiomegalia/prevención & control,
Modelos Animales de Enfermedad,
Fibrosis/inducido químicamente,
Fibrosis/prevención & control,
Citometría de Flujo,
Fumaratos/administración & dosificación,
Isoproterenol/farmacología,
Ratas Sprague-Dawley,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transducción de Señal/efectos de los fármacos,
Serina-Treonina Quinasas TOR/efectos de los fármacos,
Serina-Treonina Quinasas TOR/metabolismo
Yaylaci, Selçuk;
Dheir, Hamad;
Şenocak, Didar;
Genc, Ahmed Bilal;
Kocayigit, Havva;
Çekiç, Deniz;
Varim, Ceyhun;
Aydın, Abdülkadir;
Koroglu, Mehmet;
Karabay, Oğuz.
SUMMARY INTRODUCTION This study aims to evaluate changes in hematological parameters after the follow-up of patients who received treatment with favipiravir due to COVID-19 infections. METHODS Sixty-two cases receiving favipiravir treatment for at least five days due to COVID-19 infection were evalua...
Amidas/uso terapéutico,
Betacoronavirus,
Recuento de Linfocito CD4,
Infecciones por Coronavirus,
Infecciones por Coronavirus/tratamiento farmacológico,
Infecciones por Coronavirus/epidemiología,
Hemoglobinas/análisis,
Recuento de Leucocitos,
Persona de Mediana Edad,
Pandemias,
Recuento de Plaquetas,
Neumonía Viral/tratamiento farmacológico,
Neumonía Viral/epidemiología,
Pirazinas/uso terapéutico,
Estudios Retrospectivos
The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neurotoxic ...
Amidas/agonistas,
Cafeína/antagonistas & inhibidores,
Células/clasificación,
Economía,
Encéfalo/patología,
Fármacos Neuroprotectores/análisis,
Glutatión/farmacología,
Neuroprotección,
Oxidopamina,
Supervivencia Celular,
Sinaptosomas
Abstract Introduction: It is still unknown how the pharmacological inhibition of the Renin Angiotensin System (RAS) impacts the levels of inflammation and fibrosis biomarkers. Objective: This study sought to evaluate the effect of enalapril, candesartan and aliskiren on urinary levels of cytokines in a...
Amidas/farmacología,
Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología,
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología,
Bencimidazoles/farmacología,
Citocinas/orina,
Enalapril/farmacología,
Fumaratos/farmacología,
Nefrectomía,
Distribución Aleatoria,
Ratas Wistar,
Sistema Renina-Angiotensina/efectos de los fármacos,
Tetrazoles/farmacología
Abstract Objectives: The increase in the prevalence of obesity presents a significant health and economic problem. Obesity has been reported to be a major contributor to variety of chronic diseases. Childhood obesity has been rising over the past decades leading to various complications in health. Milli...
Amidas/administración & dosificación,
Amidas/toxicidad,
Anestesia Raquidea/efectos adversos,
Anestesia Raquidea/métodos,
Anestésicos Locales/administración & dosificación,
Anestésicos Locales/toxicidad,
Animales Recién Nacidos,
Apoptosis/efectos de los fármacos,
Bupivacaína/administración & dosificación,
Bupivacaína/toxicidad,
Caspasa 3/metabolismo,
Dieta Alta en Grasa,
Modelos Animales de Enfermedad,
Inyecciones Espinales,
Obesidad/complicaciones,
Sobrepeso/complicaciones,
Ratas Sprague-Dawley,
Ropivacaína,
Factores de Tiempo
