INTRODUCTION: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed. Therefore, the search for biomarkers contributes to the improvement and development of therapies. OBJ...
Li, Musheng;
Zhao, Junhong;
Cao, Meiwan;
Liu, Ruitao;
Chen, Guanhua;
Li, Songyu;
Xie, Yuanwen;
Xie, Jing;
Cheng, Yang;
Huang, Ling;
Su, Mingmin;
Xu, Yuxin;
Zheng, Mingyue;
Zou, Kejian;
Geng, Lanlan;
Xu, Wanfu;
Gong, Sitang.
BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our stu...
Células Epiteliales/metabolismo,
Mucosa Intestinal/metabolismo,
Mastocitos/metabolismo,
MicroARNs/metabolismo,
Células CACO-2/citología,
Claudinas/metabolismo,
Exosomas/metabolismo,
Enfermedades Inflamatorias del Intestino/metabolismo,
Ocludina/metabolismo,
Proteína de la Zonula Occludens-1/metabolismo,
Células Cultivadas,
Biología Computacional,
Permeabilidad,
Análisis de Matrices Tisulares
Abstract Purpose: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). Methods: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extrac...
Adenocarcinoma/patología,
Vasos Sanguíneos/patología,
Colágeno/análisis,
Tejido Elástico/anatomía & histología,
Músculo Liso/patología,
Clasificación del Tumor,
Neoplasias de la Próstata/patología,
Valores de Referencia,
Estudios Retrospectivos,
Células del Estroma/patología,
Análisis de Matrices Tisulares
ABSTRACT BACKGROUND: There are cases of colorectal tumors that, although small, show more aggressive evolution than large tumors. This motivated us to study whether there are any proteins capable of alerting about these changes. The aim here was to correlate the immunoexpression of the TS, p53, COX2, E...
Adenocarcinoma/mortalidad,
Adenocarcinoma/patología,
Biomarcadores de Tumor/análisis,
Neoplasias Colorrectales/mortalidad,
Neoplasias Colorrectales/patología,
Ciclooxigenasa 2/análisis,
Proteínas de Unión al ADN/análisis,
Receptores ErbB/análisis,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Estudios Longitudinales,
Homólogo 1 de la Proteína MutL/análisis,
Estadificación de Neoplasias,
Modelos de Riesgos Proporcionales,
Valores de Referencia,
Estudios Retrospectivos,
Timidilato Sintasa/análisis,
Análisis de Matrices Tisulares,
Proteína p53 Supresora de Tumor/análisis
BACKGROUND: Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to identify patients at risk of poor prognoses. METHODS: Tissue microarrays were used to m...
Biomarcadores de Tumor/metabolismo,
Proteínas de Neoplasias/metabolismo,
Neoplasias Gástricas/mortalidad,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Estadificación de Neoplasias,
Pronóstico,
Análisis de Supervivencia,
Análisis de Matrices Tisulares
Abstract Purpose: To investigate the long non-coding RNAs (lncRNAs) profile on renal ischemia reperfusion in a mouse model. Methods: Microarray analysis was used to study the expression of misregulated lncRNA in a mouse model of renal ischemia reperfusion(I/R) with long ischemia time. Quantitative re...
Regulación hacia Abajo,
Expresión Génica,
Perfilación de la Expresión Génica,
Redes Reguladoras de Genes,
Riñón/irrigación sanguínea,
Ratones Endogámicos C57BL,
ARN Largo no Codificante/análisis,
ARN Mensajero/análisis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Daño por Reperfusión/genética,
Análisis de Matrices Tisulares/métodos,
Regulación hacia Arriba
Costa-Filho, Octavio Antonio Azevedo da;
Costa, Mario Augusto Cray da;
Waaga-Gasser, Ana Maria;
Kubrusly, Luiz Fernando;
Oliveira, Luciane Bugmann Moreira de;
Collaço, Luiz Martins;
Magalhães, Maria Angélica Baron;
Gasser, Martin;
Malafaia, Osvaldo;
Ribas-Filho, Jurandir Marcondes.
Abstract Purpose: To compare wound healing performed with cold blade (CSB) and ultrasonic harmonic scalpel (UHS) in the abdominal aponeurosis of rats. Methods: Eighty Wistar rats divided into two groups and underwent midline incision in the linea alba with cold blade and harmonic ultrasonic scalpel. ...
Pared Abdominal/patología,
Pared Abdominal/cirugía,
Colágeno/fisiología,
Inmunohistoquímica,
Modelos Animales,
Ratas Wistar,
Instrumentos Quirúrgicos,
Herida Quirúrgica/patología,
Herida Quirúrgica/fisiopatología,
Análisis de Matrices Tisulares,
Procedimientos Quirúrgicos Ultrasónicos,
Cicatrización de Heridas/fisiología
INTRODUÇÃO: Os macrófagos associados ao tumor (TAM) constituem até 50% da massa tumoral do câncer de mama, sendo vitais na resposta imune inata. Essas células são dotadas de uma plasticidade a qual lhes permitem a mudança de seu fenótipo de acordo com os sinais do microambiente tumoral. Há estu...
Oral squamous cell carcinoma (OSCC) is the eighth most prevalent cancer worldwide. In recent large-scale studies, by immunohistochemistry and cluster analysis, several markers were associated with patient survival in various tumors. The aim of this study was to analyze the expression profiles of 23 prote...
BACKGROUND: This study aimed to investigate the gene expression changes associated with carcinoma-associated fibroblasts (CAFs) involving in non-small cell lung carcinoma (NSCLC). METHODS: We downloaded the GEO series GSE22862, which contained matched gene expression values for 15 CAF and normal fibrobla...
Fibroblastos Asociados al Cáncer,
Carcinoma/genética,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Pulmonares/genética,
Carcinoma/patología,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Neoplasias Pulmonares/patología,
Factor de Crecimiento Transformador beta/genética,
Alelos,
Regulación hacia Abajo,
Dosificación de Gen,
Perfilación de la Expresión Génica,
Ontología de Genes,
Estudios de Asociación Genética,
Pérdida de Heterocigocidad,
Mapas de Interacción de Proteínas,
Análisis de Matrices Tisulares,
Regulación hacia Arriba
