BACKGROUND: Quizalofop-p-ethyl (QPE), a unitary R configuration aromatic oxyphenoxypropionic acid ester (AOPP) herbicide, was widely used and had led to detrimental environmental effects. For finding the QPEdegrading bacteria and promoting the biodegradation of QPE, a series of studies were carried out. ...
Propionatos/metabolismo,
Quinoxalinas/metabolismo,
Methylobacterium/metabolismo,
Herbicidas,
Biodegradación Ambiental,
Microbiología del Suelo,
Hidrolasas/metabolismo,
Esterasas/metabolismo,
Hidrolasas/análisis,
Esterasas/análisis,
Methylobacterium/enzimología,
Análisis de Secuencia de Proteína,
Methylobacterium/genética,
Hidrólisis
Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). Methods: The purification, molecular mass determination, partial amino acid sequencing, phospholipase A2 activit...
Dermatophagoides farinae (Der f), one of the main species of house dust mites, produces more than 30 allergens. A recently identified allergen belonging to the alpha-tubulin protein family, Der f 33, has not been characterized in detail. In this study, we used bioinformatics tools to construct the second...
Alérgenos/química,
Alérgenos/genética,
Alérgenos/inmunología,
Antígenos Dermatofagoides/química,
Antígenos Dermatofagoides/genética,
Antígenos Dermatofagoides/inmunología,
Biología Computacional,
Dermatophagoides farinae/química,
Dermatophagoides farinae/genética,
Dermatophagoides farinae/inmunología,
Mapeo Epitopo,
Epítopos de Linfocito B/química,
Epítopos de Linfocito B/genética,
Epítopos de Linfocito T/química,
Epítopos de Linfocito T/genética,
Estructura Molecular,
Estructura Terciaria de Proteína,
Análisis de Secuencia de Proteína,
Tubulina (Proteína)/química,
Tubulina (Proteína)/genética,
Tubulina (Proteína)/inmunología
Animal poisons and venoms are sources of biomolecules naturally selected. Rhinella schneideri toads are widespread in the whole Brazilian territory and they have poison glands and mucous gland. Recently, protein from toads’ secretion has gaining attention. Frog skin is widely known to present great num...
BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES The aim of this work was to perform molecu...
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the...
Pérez-Ibave, Diana Cristina;
González-Alvarez, Rafael;
Martinez-Fierro, Margarita de La Luz;
Ruiz-Ayma, Gabriel;
Luna-Munoz, Maricela;
Martínez-De-Villarreal, Laura Elia;
Garza-Rodríguez, María De Lourdes;
Reséndez-Pérez, Diana;
Mohamed-Noriega, Jibran;
Garza-Guajardo, Raquel;
Bautista-De-Lucío, Victor Manuel;
Mohamed-Noriega, Karim;
Barboza-Quintana, Oralia;
Arámburo-De-La-Hoz, Carlos;
Barrera-Saldana, Hugo Alberto;
Rodríguez-Sánchez, Irám Pablo.
BACKGROUND: The olfactomedin-like domain (OLFML) is present in at least four families of proteins, including OLFML2A and OLFML2B, which are expressed in adult rat retina cells. However, no expression of their orthologous has ever been reported in human and baboon. OBJECTIVE: The aim of this study was to ...
Proteínas de la Matriz Extracelular/metabolismo,
Ojo/metabolismo,
Glicoproteínas/metabolismo,
Proteínas de la Membrana/metabolismo,
Proteínas de la Matriz Extracelular/análisis,
Proteínas de la Matriz Extracelular/genética,
Ojo/química,
Técnica del Anticuerpo Fluorescente/métodos,
Glicoproteínas/análisis,
Glicoproteínas/genética,
Proteínas de la Membrana/análisis,
Proteínas de la Membrana/genética,
Código de Barras del ADN Taxonómico,
Evolución Molecular,
Fenómenos Fisiológicos Oculares,
Papio,
Valores de Referencia,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transcripción Reversa,
Análisis de Secuencia de Proteína
The current state of the art in medical genetics is to identify and classify the functional (deleterious) or non-functional (neutral) single amino acid substitutions (SAPs), also known as non-synonymous SNPs (nsSNPs). The primary goal is to elucidate the mechanisms through which functional SAPs exert the...
Background Snake venoms are complex mixtures of inorganic and organic components, mainly proteins and peptides. Standardization of methods for isolating bioactive molecules from snake venoms is extremely difficult due to the complex and highly variable composition of venoms, which can be influenced by fa...
