Abstract The renin-angiotensin-aldosterone system (RAAS) plays a key role in diabetic nephropathy (DN). Angiotensin-II secreted during the RAAS pathway increases nephropathy. It stimulates oxidative stress which can quench nitric oxide. Reduced nitric oxide level aggravates Ang-II-induced vasoconstrictio...
Introdução:uma vez conhecidos os mecanismos de patogênese do SARS-CoV-2, vários métodos de tratamento para a COVID-19 foram desenvolvidos, dentre eles destaca-se o uso dos anticorpos monoclonais para o contexto de pacientes em estágios graves da doença. Objetivo: compreender se o ...
Angiotensin-II (AgII) is thought to be crucial for tumor growth and progression. Moreover, hydrogen sulfide (H2S) performs a controversial action in cancer pathology. Zofenopril (ZF) is an angiotensin-converting enzyme (ACE) inhibitor with H2S donating properties. Hence, this study aims at investigating ...
O diabetes mellitus (DM) é um grande problema de saúde pública, que afeta cerca de 463 milhões de pessoas no mundo e pode alcançar 700 milhões de pessoas até 2045. A nefropatia é uma das complicações microvasculares do diabetes e a maior causa de insuficiência renal. Uma vez que a ativação d...
Sun, Bo;
Li, Fangda;
Lai, Song;
Zhang, Xu;
Wang, Hongxia;
Li, Yuan;
Wang, Wei;
Chen, Yuexin;
Liu, Bao;
Zheng, Yuehong.
ABSTRACT Purpose To investigate the relationship between atherosclerotic abdominal aortic aneurysm (AAA) and CXC chemokine receptor type 2 (CXCR2). Methods Mouse AAA model was established by embedding angiotensin-II pump (1000 ng/kg/min) in ApoE-/- mice. Mice were received SB225002, a selective CXCR2 a...
ABSTRACT Purpose: The renin-angiotensin system is involved in the pathogenesis of retinal ischemic conditions and glaucoma. Our objective was to evaluate the renin, angiotensinconverting enzyme 1, and angiotensin-converting enzyme 2 activities in aqueous humor and blood samples of patients with and with...
Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) ...
Amidas/administración & dosificación,
Angiotensina II/farmacología,
Apoptosis/efectos de los fármacos,
Western Blotting,
Cardiomegalia/inducido químicamente,
Cardiomegalia/metabolismo,
Cardiomegalia/prevención & control,
Modelos Animales de Enfermedad,
Fibrosis/inducido químicamente,
Fibrosis/prevención & control,
Citometría de Flujo,
Fumaratos/administración & dosificación,
Isoproterenol/farmacología,
Ratas Sprague-Dawley,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transducción de Señal/efectos de los fármacos,
Serina-Treonina Quinasas TOR/efectos de los fármacos,
Serina-Treonina Quinasas TOR/metabolismo
A insuficiência cardíaca (IC) é uma síndrome de elevada morbimortalidade, correspondendo a um grave problema de saúde pública. Uma das abordagens terapêuticas para IC consiste no uso de antagonistas do receptor de angiotensina II do tipo 1 (AT1R), conhecidos como sartanas. Estudos apontam que uma ...
The Gαq-RGS2 loop activator, 1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)-phenyl)-1H-1,2,4-triazol-5(4H)-one has demonstrated Gαq signaling inhibitor activity. Therefore, we aimed to study the effect of Gαq-RGS2 loop activator on isolated heart and aorta of normal rats. Heart and aorta were iso...
Los Inhibidores de la enzima convertidora de angiotensina II (IECAs) y
antagonistas de los receptores de angiotensina II (ARA II) son drogas usadas
comúnmente en el manejo de hipertensión arterial, sin embargo, su uso en el
embarazo está asociado con toxicidad fetal.1, 2 La acción de la angiotensina
...
