LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Gestation and breastfeeding in schistosomotic mice differentially alters the expression of histone deacetylases (HDACs) in adult offspring

Holanda, Gabriela Calixto Ribeiro de; Souto, Fabrício Oliveira; Silva, Maria da Conceição; Lorena, Virgínia Maria Barros de; Costa, Vlaudia Maria Assis; Albuquerque, Monica Camelo Pessôa de Azevedo; Souza, Valdênia Maria Oliveira de; Lima Filho, José Luiz de.

Mem. Inst. Oswaldo Cruz; 114 (), 2019

BACKGROUND Breastfeeding or gestation in schistosomotic mothers can cause long-term alterations in the immune response of offspring. OBJECTIVES Evaluate the expression of histone deacetylases (HDACs) (all classes), the production of cytokines by T and B lymphocytes and macrophages, and the frequency o...

Animales Lactantes/metabolismo, Animales Lactantes/parasitología, Lactancia Materna, Modelos Animales de Enfermedad, Histona Desacetilasas/metabolismo, Inmunidad Materno-Adquirida, Complicaciones Parasitarias del Embarazo, Esquistosomiasis mansoni/metabolismo, Bazo/química

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Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (...