Efficacy (success of therapy under ideal conditions), efficiency (the relationship between the costs and outcomes of a specific intervention), and effectiveness (the balance between efficacy and efficiency in clinical practice) are measures used to evaluate health interv...
Nocardiosis is a rare infectious disease caused by a group of bacteria of the genus Nocardia in immunocompromised patients and can affect practically any organ, the most common being the lung, central nervous system and skin. We present the case of a patient with primary focal and segmental glomeruloscle...
Nocardiosis/diagnóstico,
Nocardiosis/tratamiento farmacológico,
Glomeruloesclerosis Focal y Segmentaria/tratamiento farmacológico,
Glomeruloesclerosis Focal y Segmentaria/etiología,
Anticuerpos Monoclonales/uso terapéutico,
Imipenem/administración & dosificación,
Imipenem/uso terapéutico,
Linezolid/administración & dosificación,
Linezolid/uso terapéutico,
Nocardia/inmunología,
Autoanticuerpos/sangre,
Autoanticuerpos/inmunología,
Técnicas de Laboratorio Clínico,
Tomografía Computarizada por Rayos X,
Espectroscopía de Resonancia Magnética
Introduction: Lyme disease, caused by Borrelia burgdorferi, can lead to diverse neurological manifestations, including headache. While most Lyme-associated headaches resolve with antibiotics, some may evolve into a refractory chronic migraine-like syndrome. We present a case of post-Lyme chronic migraine...
Spessatto, Gabriela;
Fajardo, Aline Didoni;
Primon, Juliana Gonçalves;
Picciani, Thalita Gonçalves;
Martins, Guilherme da Silva;
João, Bruno Hernandes David;
Carvalho, Larissa Machado;
Noriega, Angelica Fonseca;
Saab, Maitê Milagres;
Miranda, Tayna Padilha;
Rosário, Cristine Secco;
Araujo, Laura Maria Lacerda;
Riedi, Carlos Antônio;
Cunha, Roberta Corrêa da;
Eli, Denise;
Silva, Débora Carla Chong;
Chong-Neto, Herberto J;
Rosário Filho, Nelson Augusto.
A maioria das crianças e adolescentes com asma grave apresenta fenótipo de inflamação eosinofílica, com risco de exacerbações, uso de corticosteroides sistêmicos e redução na qualidade de vida. Crianças com inflamação tipo 2 respondem bem aos tratamentos convencionais, no entanto, há um gru...
This retrospective study aimed to investigate the relationship between peripheral blood basophil counts and response to treatment with omalizumab in patients with chronic spontaneous urticaria (CSU). Most patients included in the study had a normal basophil count, but a significant correlation was found ...
Alzheimer’s disease is the leading cause of dementia worldwide and a critical public health problem. While deaths from cardiovascular diseases have decreased, those attributed to Alzheimer’s disease have increased in recent years with no curative treatment to date. In this context, effective treatmen...
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease of the esophagus characterized by symptoms
of esophageal dysfunction such as dysphagia, food impaction, and chest pain in adults. It is associated with atopic di-
seases such as allergic rhinitis, atopic dermatitis, and asthma. Diagnosi...
Bendelman, Gisela;
Carretero, Marcelina;
Pérez de Arenaza, Diego;
Villanueva, Eugenia;
Brulc, Erika B;
Nucifora, Elsa M;
Marco, María A;
Sáez, María S;
Sorroche, Patricia B;
Aguirre, María A;
Posadas Martínez, María L.
La amiloidosis AL es una enfermedad debida al depósito, en órganos y tejidos, de fibrillas formadas por cadenas livianas producidas de forma patológica por plasmocitos clonales. Su tratamiento actualmente está orientado a erradicar el clon de células plasmáticas; este históricamente se extrapoló ...
Relato de caso de paciente com rinossinusite crônica com polipose nasal em tratamento com dupilumabe. São descritos os aspectos clínicos e o impacto na qualidade da vida do paciente. Imagens tomográficas evidenciam a melhora do processo inflamatório e a regressão dos pólipos nasais....
Nas últimas décadas, os anticorpos monoclonais (AcM) promoveram uma transformação dramática no tratamento de diversas doenças, especialmente nos linfomas, leucemias, câncer de mama e câncer colorretal. Estima-se que atualmente as indústrias de biotecnologia ligadas ao desenvolvimento de AcM são...
