Results: 74

Interação B1R/TLR4 como mecanismo de resposta inflamatória e sua implicação na barreira hematoencefálica em modelo de glioblastoma
B1R/TLR4 interaction as a mechanism of inflammatory response and its implication on the blood-brain barrier in glioblastoma model

A família dos receptores de cininas compreende dois subtipos, sendo o B1R aquele em tem como um de seus agonistas fisiológicos a des-Arg9 -BK (DBK). O receptor B1 tem baixa expressão ou está até mesmo ausente em condições fisiológicas normais, podendo ser induzido por vários estímulos, como o p...

Estudo da influência da matriz extracelular de glioblastoma no perfil angiogênico de células endoteliais da microvasculatura cerebral e na sobrevida global de pacientes
Study of the influence of glioblastoma extracellular matrix on the angiogenic profile of endothelial cells of the cerebral microvasculature and on the overall survival of patients

Glioblastomas (GBM) são conhecidos como os tumores mais comuns e letais que se desenvolvem no sistema nervoso central. Eles são considerados os gliomas difusos mais agressivos e que possuem alta resistência a tratamentos de radioterapia e quimioterapia, além de serem um dos tumores mais vascularizado...

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells

Biol. Res; 57 (), 2024
BACKGROUND: Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxicity and the development and/or exacerbation of neuropathological manifestations, i...

Hemangiolinfangioma mesentérico: reporte de un caso

Med. lab; 27 (1), 2023
El hemangiolinfangioma es un tipo muy raro de malformación del sistema vascular, caracterizado histológicamente por la presencia de vasos venosos y linfáticos dilatados quísticamente, cuyas células endoteliales de revestimiento son positivas para marcadores de inmunohistoquímica como CD31, CD34 y D...

Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells

Abstract Dill (Anethum graveolens L.) essential oil is wide spread in the food, beverage and pharmaceutical sectors. Dill is a member of the Apiaceae (Umbelliferae) family. It has the following biological activities: antioxidant, antifungal, antibacterial, antimicrobial, antihyperlipidemic, antihyperchol...

Eucommia ulmoides extract attenuates angiotensin II-induced cardiac microvascular endothelial cell dysfunction by inactivating p53

Abstract Angiotensin II (AngII) causes endothelial dysfunction. Eucommia ulmoides extract (EUE) is documented to manipulate AngII, but its impact on cardiac microvascular endothelial cell (CMVEC) function remains unknown. This study determines the effects of EUE on AngII-treated CMVECs. CMVECs were trea...

Estudo translacional sobre o transtorno do espectro alcoólico fetal (TEAF): dados sobre o consumo materno, ensaios estruturais, funcionais e proteômicos para identificação de moléculas que alteram a barreira hematoencefálica
Translational study on fetal alcohol spectrum disorder (FASD): data on maternal consumption, structural, functional and proteomic assays to identify molecules that alter the blood-brain barrier

O consumo de bebidas alcoólicas durante a gestação representa um grande problema de saúde pública. No mundo, cerca de 10% das mulheres relatam o consumo de álcool durante a gestação, evento que pode promover o estabelecimento dos transtornos do espectro alcoólico fetal (TEAF), sendo a síndrome ...

Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis

Biol. Res; 56 (), 2023
BACKGROUND: Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulation (DIC) is frequently observed in septic patients and is assoc...

Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model

Biol. Res; 56 (), 2023
BACKGROUND/AIMS: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular protection and ischemic tissue ...

Curcumin-rich extract from Central Brazil Curcuma longa protects human umbilical vein endothelial cells under oxidative stress

ABCS health sci; 47 (), 2022
INTRODUCTION: In vascular diseases, the interruption of the local blood flow and the subsequent reperfusion of oxygen can cause deleterious oxidative effects on the cells. Turmeric (Curcuma longa L.) presents the capacity to neutralize free radicals along with preventive and therapeutic effects for sever...