Results: 10

Clinical studies using stem cells for treatment of retinal diseases: state of the art

Arq. bras. oftalmol; 83 (2), 2020
ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt's macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promisi...

Mesenchymal stem cells reduce left ventricular mass in rats with doxorubicin-induced cardiomyopathy

Int. j. morphol; 36 (1), 2018
SUMMARY: Doxorubicin is a drug that used by a majority in the treatment of carcinomas. The most obvious known side effect is cardiomyopathy. Many studies have been carried out to eliminate side effects of the doxorubicin, and stem cell studies have been added in recent years. In this study, it was aimed ...

Single-cell qPCR facilitates the optimization of hematopoietic differentiation in hPSCs/OP9 coculture system

Braz. j. med. biol. res; 51 (5), 2018
Human pluripotent stem cells (hPSCs)/OP9 coculture system is a widely used hematopoietic differentiation approach. The limited understanding of this process leads to its low efficiency. Thus, we used single-cell qPCR to reveal the gene expression profiles of individual CD34+ cells from different stages o...

Current challenges in the therapeutic use of induced pluripotent stem cells (iPSCs) in cancer therapy

Appl. cancer res; 37 (), 2017
Induced Pluripotent Stem Cells (iPSCs) technology has catapulted the field of stem-cell biology through ectopic expression of reprogramming factors. Ever since its discovery, the potential of iPSCs has been explored by many scientists to unravel the molecular mechanism responsible for cancer initiation a...

Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells

Biol. Res; 50 (), 2017
BACKGROUND: Kidney diseases are a global health problem. Currently, over 2 million people require dialysis or transplant which are associated with high morbidity and mortality; therefore, new researches focused on regenerative medicine have been developed, including the use of stem cells. RESULTS: In thi...

Membrana amniótica: fonte alternativa de células-tronco mesenquimais em diversas espécies animais

Pesqui. vet. bras; 36 (6), 2016
O crescente interesse do uso de células-tronco (CTs) na medicina regenerativa, estão baseadas na sua capacidade de autorrenovação, reparação tecidual e imunomodulação. A terapia utilizando células-tronco é uma ciência em formação considerada uma alternativa terapêutica promissora no tratame...

Células Troncales en el Desarrollo y las Perspectivas de Reprogramación Celular para la Regeneración

Int. j. morphol; 30 (4), 2012
Los organismos multicelulares se desarrollan a partir de una sola célula: el cigoto. A lo largo de su ontogenia, las células que derivan del cigoto despliegan distintos programas celulares, los cuales son estabilizados por mecanismos epigenéticos. Los programas de las células troncales son más inclu...

Potencialidad Celular Evolutiva y Medicina Regenerativa

Int. j. morphol; 30 (4), 2012
Las células derivadas del embrioblasto o macizo celular interno (MCI) del blastocisto corresponden a las células madres embrionarias, ellas son pluripotentes, debido a que tienen la capacidad de generar todas las estirpes celulares y al resto, se les conoce como células madres adultas porque tienen un...

Polimorfismo do gene tp53 no códon 72 em pacientes com suspeita de LMC
Codon 72 polymorphism of the TP53 gene in patients suspected to have CML

A leucemia mielóide crônica (LMC) é uma doença proliferativa do sistema hematopoiético, caracterizada pela expansão clonal de uma célula-tronco primitiva e pluripotente denominada stem cell. Este tipo de leucemia está associado, em 90 por cento dos casos, à translocação t(9;22)(q34;q11). Essa ...