As lesões odontogênicas epiteliais benignas constituem um grupo heterogêneo de lesões. A proteína CLIC4 atua na regulação dos processos de parada de crescimento e apoptose, participando também do processo de transdiferenciação dos fibroblastos em miofibroblastos que passam a expressar α-SMA. A...
Os tumores de glândula salivar (TGS) apresentam notável complexidade clínica e biológica, razão para a qual muitos estudos investigam os eventos envolvidos na sua progressão. Uma das dinâmicas envolvidas na invasão tumoral de diversos tipos de carcinomas é a transição epitélio-mesênquima (TE...
Os cistos e tumores odontogênicos, lesões que acometem o complexo maxilomandibular,
podem exibir comportamento clínico-biológico mais agressivo. E a transição epitelialmesenquimal (TEM), processo pelo qual as células epiteliais perdem propriedades fenotípicas
e adquirem características de célul...
Quistes Odontogénicos/patología,
Tumores Odontogénicos/patología,
Transición Epitelial-Mesenquimal,
Vimentina/metabolismo,
Cadherinas/metabolismo,
Distribución de Chi-Cuadrado,
Estadísticas no Paramétricas,
Estudio Observacional,
Estudios Retrospectivos,
Estudios Prospectivos,
Registros Médicos
Cisplatin, the first platinum compound approved for cancer treatment, is widely used in the treatment of various cancers including hepatocellular carcinoma (HCC). HCC incidence rates rise globally. Epithelial mesenchymal transition (EMT) is implicated in cancer invasion and metastasis, which are associat...
Cisplatino/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Microscopía Confocal,
Células Cultivadas,
Antineoplásicos/administración & dosificación,
Cadherinas/efectos de los fármacos,
Cadherinas/genética,
Vimentina/efectos de los fármacos,
Vimentina/genética,
Factores de Transcripción de la Familia Snail/efectos de los fármacos,
Factores de Transcripción de la Familia Snail/genética,
Técnica del Anticuerpo Fluorescente,
Cadherinas/metabolismo,
Vimentina/metabolismo,
Factores de Transcripción de la Familia Snail/metabolismo,
Células Hep G2,
Invasividad Neoplásica,
Transición Epitelial-Mesenquimal
SUMMARY: Diabetes is a metabolic disorder characterized by high blood sugar levels and it causes complications in many systems, including the reproductive system. As a result of diabetic conditions, one of the mechanisms that can cause repression of reproductive activity is testicular oxidant stress. The...
ABSTRACT Purpose: To evaluate the effects of sucralfate enemas in tissue contents of E-cadherin and ?-catenin in an experimental diversion colitis. Methods: Thirty-six male Wistar rats were submitted to a proximal colostomy and a distal mucous fistula. They were allocated into three groups: first group...
Abstract Heterogeneous cell populations of osteo/cementoblastic (O/C) or fibroblastic phenotypes constitute the periodontal dental ligament (PDL). A better understanding of these PDL cell subpopulations is essential to propose regenerative approaches based on a sound biological rationale. Objective Our...
Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity...
Lesión Pulmonar Aguda/inducido químicamente,
Lesión Pulmonar Aguda/tratamiento farmacológico,
Antígenos CD/efectos de los fármacos,
Antígenos CD/metabolismo,
Cadherinas/efectos de los fármacos,
Cadherinas/metabolismo,
Modelos Animales de Enfermedad,
Proteína HMGB1/efectos de los fármacos,
Proteína HMGB1/metabolismo,
Lipopolisacáridos,
Metilprednisolona/administración & dosificación,
Ratas Sprague-Dawley,
Saquinavir/administración & dosificación,
Transducción de Señal/efectos de los fármacos,
Receptor Toll-Like 4/efectos de los fármacos,
Receptor Toll-Like 4/metabolismo
Abstract To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with...
