The role of pioglitazone in antioxidant, anti-inflammatory, and insulin sensitivity in a high fat-carbohydrate diet-induced rat model of insulin resistance
Braz. j. med. biol. res; 54 (8), 2021
We explored the cascade effects of a high fat-carbohydrate diet (HFCD) and pioglitazone (an anti-diabetic therapy used to treat type 2 diabetes mellitus (T2DM)) on lipid profiles, oxidative stress/antioxidant, insulin, and inflammatory biomarkers in a rat model of insulin resistance. Sixty albino rats (8...
Antiinflamatorios/farmacología, Antioxidantes/farmacología, Carbohidratos/farmacología, Diabetes Mellitus Tipo 2/tratamiento farmacológico, Diabetes Mellitus Tipo 2/metabolismo, Dieta Alta en Grasa, Insulina/metabolismo, Resistencia a la Insulina, Hígado/metabolismo, Estrés Oxidativo, Pioglitazona/metabolismo, Pioglitazona/farmacología