Abstract Matrix degradation is an important event in the progression, invasion and metastasis of malignant head and neck lesions. Imbalances, mutations and polymorphisms of MMPs and their inhibitors are observed in several cancer subtypes. The aim of this study was to evaluate the association of the MMP-...
Circular RNAs (circRNAs) have been extensively elucidated with regard to their significant implications in oral squamous cell carcinoma (OSCC). This study performed the functional investigation of circRNA dehydrogenase E1 and transketolase domain containing 1 (circDHTKD1) in OSCC. RNA expression levels o...
The aim of this study was to explore the effect of hsa_circ_0002162 on regulating cell proliferation, apoptosis, and invasion, and investigate its potential target microRNA (miRNA) in tongue squamous cell carcinoma (TSCC). Hsa_circ_0002162 expression was detected in human TSCC cell lines and human oral k...
Abboud, H S;
Camuzi, D;
Rapozo, D C;
Fernandes, P V;
Nicolau-Neto, P;
Guaraldi, S;
Simão, T A;
Ribeiro Pinto, L F;
Gonzaga, I M;
Soares-Lima, S C.
Esophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors have been developed, such as HGF-MET targeted therapy. We assessed MET and HGF genetic a...
Abstract Micro-RNA-221(miR-221) is one of oncogenic miRNAs that plays a vital role in the development and progression of oral cancers. The aim of this study is to introduce a new gene therapy for oral squamous cell carcinoma by blocking the expression of oncogenic miR-221 by its inhibitor. The present wo...
Apoptosis,
Carcinoma de Células Escamosas/genética,
Carcinoma de Células Escamosas/terapia,
Línea Celular Tumoral,
Proliferación Celular,
Terapia Genética,
MicroARNs/antagonistas & inhibidores,
MicroARNs/genética,
MicroARNs/uso terapéutico,
Neoplasias de la Boca/genética,
Neoplasias de la Boca/terapia
LINC00355 has been reported aberrantly over-expressed and associated with poor prognosis in various types of cancer. However, reports regarding the effect of LINC00355 on lung squamous cell carcinoma (SCC) are rare. This study aimed to explore the function of LINC00355 in the development and progression ...
Abstract: Objective: To review the state-of-the-art in relation to the current information on squamous cell lung cancer (SCLC). We describe the genetic anomalies reported, their effect, and finally the most promising therapeutic agents. Materials and methods: We reviewed published articles in peer-re...
Introdução: A neoplasia do pênis é uma doença rara, sendo mais frequente nos países em desenvolvimento. Representa 0,4%dos tumores malignos dos homens nos EUA e 2,1% no Brasil, sendo mais prevalente nas regiões norte e nordeste. O carcinoma epidermóide representa aproximadamente 95% das neoplasia...
Abstract Objective The current study evaluated the expression of WW domain-containing oxidoreductase (WWOX), its association with clinicopathological features and with p53, Ki-67 (cell proliferation) and CD31 (angiogenesis) expression in patients with invasive cervical squamous cell carcinoma (ICSCC). ...
Carcinoma de Células Escamosas/química,
Carcinoma de Células Escamosas/genética,
Carcinoma de Células Escamosas/patología,
Proliferación Celular,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Persona de Mediana Edad,
Neovascularización Patológica,
Estudios Prospectivos,
Proteína p53 Supresora de Tumor/análisis,
Proteína p53 Supresora de Tumor/genética,
Proteínas Supresoras de Tumor/análisis,
Proteínas Supresoras de Tumor/genética,
Neoplasias del Cuello Uterino/química,
Neoplasias del Cuello Uterino/genética,
Neoplasias del Cuello Uterino/patología,
Oxidorreductasa que Contiene Dominios WW/análisis,
Oxidorreductasa que Contiene Dominios WW/genética
