In this study, the protectivity of silymarin (SY) against the harmful effects of paclitaxel (PX) on the heart was investigated. PX was administered 2 mg/kg intraperitoneally to the PX group, 100 mg/kg SY wasadministered by gavage to the SY group, and both drugs were administered to the PX + SY group...
SUMMARY: Etoposide is an effective antimitotic and antineoplastic agent used to treat various human malignancies. In the present study, Etoposide was injected intraperitoneally into the rats at 1 mg/kg/day for 52 days (52 doses). The control animals received physiological saline (0.5 ml) intraperitoneall...
Etopósido/administración & dosificación,
Etopósido/farmacología,
Peso Corporal/efectos de los fármacos,
Tamaño de los Órganos/efectos de los fármacos,
Peroxidación de Lípido,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Hígado/efectos de los fármacos,
Hígado/ultraestructura,
Riñón/efectos de los fármacos,
Riñón/ultraestructura,
Corazón/efectos de los fármacos,
Miocardio/ultraestructura,
Sistema Enzimático del Citocromo P-450/análisis,
Citocromos b5/análisis,
Ratas Wistar,
Microscopía,
Antineoplásicos Fitogénicos
SUMMARY: In response to the threat posed by new variants of SARS-CoV-2 and the urgent need for effective treatments in the absence of vaccines, the aim of this study was to develop a rapid and cost-effective hyperimmune serum (HS) derived from sheep and assess its efficacy. The utilization of a halal-cer...
COVID-19/tratamiento farmacológico,
Inmunoterapia/métodos,
Sueros Inmunes/administración & dosificación,
COVID-19/prevención & control,
COVID-19/inmunología,
SARS-CoV-2/efectos de los fármacos,
Sistema Respiratorio/efectos de los fármacos,
Corazón/efectos de los fármacos,
Vacunas de Productos Inactivados,
Caballos,
Ovinos,
Citometría de Flujo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Microscopía Electrónica de Transmisión,
Síndrome Respiratorio Agudo Grave/prevención & control,
Insuficiencia Multiorgánica/prevención & control,
Sistema Respiratorio/ultraestructura,
Miocardio/ultraestructura
Elkattawy, Hany A;
El-Sayed-Hassan, Ahmed;
Ebrahim-Alsemeh, Amira;
Abdelwahab, Ola A;
Eldesoqui, Mamdouh;
El-Sherbiny, Mohamed;
Ebrahim, Hasnaa Ali;
Nosseir, Nermine Samir;
Veeraraghavan, Vishnu Priya;
Ghazala, Mohamed;
Attia, Mohammed A;
Hadhoud, Shimaa.
SUMMARY: The main cause of mortality and disability globally is myocardial infarction (MI). Isoproterenol (ISO), a β-adrenoceptor agonist, has been used to induce rat myocardial necrosis. Whereas interleukin-37 (IL-37) has anti-inflammatory and cytoprotective properties. The study aimed to investiga...
SUMMARY: Magnolia bark extract supplementation has an anti-oxidative role in mammalians. However, its role in physiological aged-associated heart insufficiency is not known yet. Therefore, we investigated the effects of a magnolia bark complex, including magnolol and honokiol components (MAHOC), in elder...
RESUMEN: La solución de formol es utilizada en las Escuelas de medicina como medio de fijación y conservación de cadáveres para el estudio de la Anatomía, a la que están expuestos estudiantes, técnicos y personal docente; es alergénica e irritante a las mucosas, y reconocida carcinogénica en hum...
Abstract Background Various studies are ongoing related to the radioprotective agents. Herbal preparations are currently becoming popular because of their beneficial effects with fewer side effects compared to the synthetic/semi-synthetic medicines, and Nigella sativa oil (NSO) is only one of them. Ob...
Nigella sativa,
Antioxidantes/uso terapéutico,
Ratas Wistar,
Cardiotoxicidad/tratamiento farmacológico,
Estrés Oxidativo/efectos de la radiación,
Estrés Oxidativo/efectos de los fármacos,
Fitoterapia,
Preparaciones de Plantas/uso terapéutico,
Aceites de Plantas/uso terapéutico,
Plantas Medicinales,
Protectores contra Radiación/análisis,
Corazón/efectos de los fármacos,
Corazón/efectos de la radiación,
Protectores contra Radiación/uso terapéutico,
Ratas Endogámicas
ABSTRACT Objective Acrylamide is a toxic compound widely used in industrial sectors. Acrylamide causes reactive oxygen species formation and the subsequent lipid peroxidation reaction, which plays an important role in the pathogenesis of oxidative damage. Taxifolin is a flavonoid with antioxidant proper...
SUMMARY: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent a unique class of glucose-declining renal-targeted drugs. The SGLT2i Canagliflozin (CANA) is an anti-hyperglycemic drug that reduces various cardiovascular and renal outcomes in patients with type 2 diabetes mellitus. This study aimed ...
Abstract 22-year-old male patient with no heart disease, who was given an ambulatory medication with analgesics due to an acute renal crisis. After the drug administration, the patient presented dyspnea, cyanosis, and hemoptysis. There was suspicion of anaphylactic shock, which was treated, but there was...
