LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Neurotrophic Factor Mediated Neurorestorative Effect of Pongamia pinnata Against Transient Cerebral Hypoperfusion and Reperfusion in Rats: Preliminary Histological and Molecular Level Evidence

Suganitha, Balasundaram; Jagadeesan, Vijayakumar; Sivanesan, Senthilkumar; Prathap, Lavanya; Mundugaru, Ravi; Alzerwi, Nasser; Saraswathi, Ilango; Saikarthik, Jayakumar.

Int. j. morphol; 42 (3), 2024

SUMMARY: Stroke is the leading cause of acquired physical disability in adults and second leading cause of mortality throughout the world. Treatment strategies to curb the effects of stroke would be of great benefit. Pongamia pinnata is a recent attraction in medicine, owing to its abundant medicinal ben...

Millettia/química, Extractos Vegetales/administración & dosificación, Extractos Vegetales/farmacología, Accidente Cerebrovascular/tratamiento farmacológico, Ratas Wistar, Modelos Animales de Enfermedad, Corteza Cerebral/efectos de los fármacos, Isquemia Encefálica/tratamiento farmacológico, Factor Neurotrófico Derivado del Encéfalo/genética, Factor Neurotrófico Derivado de la Línea Celular Glial/genética, Factor 1 Inducible por Hipoxia/genética, FN-kappa B, Administración Oral, Reacción en Cadena en Tiempo Real de la Polimerasa, Factores de Crecimiento Nervioso/administración & dosificación

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Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex

Sousa, Mariana Séfora Bezerra; Holanda, Iasmym Melissa Soares de; Monteiro, Heloísa Mirelle Costa; Amâncio-dos-Santos, Ângela.

Acta cir. bras; 33 (6), 2018

Abstract Purpose: To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress. Methods: Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage...

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Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson's disease

Rajaei, Z; Hosseini, M; Alaei, H.

Arq. neuropsiquiatr; 74 (9), 2016

ABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle a...

Antioxidantes/farmacología, Carotenoides/farmacología, Corteza Cerebral/efectos de los fármacos, Corteza Cerebral/metabolismo, Corteza Cerebral/fisiopatología, Modelos Animales de Enfermedad, Glutatión Peroxidasa/análisis, Glutatión Peroxidasa/efectos de los fármacos, Peroxidación de Lípido/efectos de los fármacos, Memoria/efectos de los fármacos, Memoria/fisiología, Trastornos de la Memoria/metabolismo, Trastornos de la Memoria/fisiopatología, Trastornos de la Memoria/prevención & control, Nitritos/análisis, Estrés Oxidativo/efectos de los fármacos, Oxidopamina, Enfermedad de Parkinson/tratamiento farmacológico, Enfermedad de Parkinson/metabolismo, Enfermedad de Parkinson/fisiopatología, Distribución Aleatoria, Ratas Wistar, Compuestos de Sulfhidrilo/análisis, Sustancias Reactivas al Ácido Tiobarbitúrico/análisis

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Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1

Kaya, Kürşat; Ciftci, Osman; Cetin, Aslı; Tecellioğlu, Mehmet; Başak, Neşe.

Acta cir. bras; 31 (3), 2016

ABSTRACT PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally....

Antineoplásicos/efectos adversos, Encefalopatías/prevención & control, Encéfalo/efectos de los fármacos, Cisplatino/efectos adversos, beta-Glucanos/farmacología, Antineoplásicos/metabolismo, Encéfalo/metabolismo, Encéfalo/patología, Encefalopatías/inducido químicamente, Encefalopatías/patología, Corteza Cerebral/efectos de los fármacos, Corteza Cerebral/metabolismo, Corteza Cerebral/patología, Cisplatino/metabolismo, Modelos Animales, Estrés Oxidativo, Sustancias Protectoras/farmacología, Distribución Aleatoria, Ratas Sprague-Dawley

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