Results: 2

Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex

Acta cir. bras; 33 (6), 2018
Abstract Purpose: To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress. Methods: Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage...

Brimonidine tartrate effect on retinal spreading depression depends on Müller cells

Rev. bras. oftalmol; 73 (6), 2014
Objective: Demonstrate the Brimonidine effect over Retinal Spreading Depression (SD). Brimonidine is an alpha-2–adrenergic receptor agonist, used in the management of glaucoma. Alpha2-agonists have been shown to be neuroprotective in various experimental models, however the molecular and cellular t...