Abstract Diltiazem hydrochloride (DLH) is a calcium channel blocker useful for the treatment of angina pectoris, arrhythmia, and hypertension. DLH having a short half-life needs frequent administration for successful treatment but this poses a problem of poor patient compliance. These requirements are se...
Bloqueadores de los Canales de Calcio/administración & dosificación,
Cinética,
Comprimidos,
Diltiazem/análisis,
Gestión de la Calidad Total/clasificación,
Industria Farmacéutica/clasificación,
Semivida,
Métodos,
Organización y Administración,
Necesidades y Demandas de Servicios de Salud,
Tamizaje Masivo,
Sistemas de Liberación de Medicamentos
Unal, Orcun;
Ulukan, Mustafa Ozer;
Bakuy, Vedat;
Kaytaz, Behiye;
Artan, Sevilhan;
Aral, Erinc;
Oztas, Didem Melis;
Beyaz, Metin Onur;
Ugurlucan, Murat;
Sevin, Behcet.
Abstract Objective: To detect and to compare the apoptotic effects of intraoperatively topically applied diltiazem, papaverine, and nitroprusside. Methods: Internal thoracic artery segments of ten patients were obtained during coronary bypass grafting surgery. Each internal thoracic artery segment wa...
A fissura anal é uma laceração do revestimento do canal anal inferior. É uma das patologias benignas anorretais mais comuns e, em muitos casos, resolve-se espontaneamente. Sua prevalência é igual entre os sexos e é mais comum em adultos jovens. A grande maioria das fissuras são primárias e causa...
The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to cl...
The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immed...
Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism. Formulation of diltiazem hydrochloride into an oro-dispersible dosage form can provide fast relief with higher bioavailab...
Diltiazem (DLTZ) es un inhibidor de la metabolización de la ciclosporina (C y A) y se usa en el paciente transplantado para disminuir las dosis de C y A. Sin embargo, por el mecanismo de acción de DLTZ esta estrategia se asocia a una mayor proporción de metabolitos de C y A circulantes. Existen en el ...
Foram avaliadas duas especialidades farmaceuticas contendo cloridrato de diltiazem na dosagem de 120mg, sob a forma de capsulas e comprimidos de açäo prolongada, visando a comparacao do perfil de dissoluçäo do farmaco. Como meios de dissoluçäo, empregaram-se agua destilada e soluçäo aquosa com va...
PURPOSE: The efficacy and safety of diltiazen 240mg was evaluated in essential hypertensive patients with diastolic pressure in the range of 95 to 115 mmHg. METHODS: In an open, non-comparative multicenter trial 2.165 hypertensives had the supine and orthostatic arterial blood pressure measured before, a...
