LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Antioxidant effect of endothelin-1 receptor antagonist protects the rat kidney against chronic injury induced by hypertension and hyperglycemia

Caires, Agnaldo; Convento, Marcia Bastos; Castino, Bianca; Leme, Ala Moana; Pessoa, Edson de Andrade; Aragão, Alef; Schor, Nestor; Borges, Fernanda Teixeira.

J. bras. nefrol; 41 (4), 2019

ABSTRACT Hypertension and Diabetes mellitus are the two main causes of chronic kidney disease that culminate in the final stage of kidney disease. Since these two risk factors are common and can overlap, new approaches to prevent or treat them are needed. Macitentan (MAC) is a new non-selective antagonis...

Administración Intravenosa, Antibióticos Antineoplásicos/administración & dosificación, Antioxidantes/farmacología, Antagonistas de los Receptores de Endotelina/administración & dosificación, Antagonistas de los Receptores de Endotelina/uso terapéutico, Endotelina-1/metabolismo, Hiperglucemia/inducido químicamente, Hiperglucemia/complicaciones, Hipertensión/complicaciones, Hipertensión/fisiopatología, Riñón/efectos de los fármacos, Riñón/lesiones, Riñón/fisiopatología, Ratas/genética, Factores de Riesgo

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Protective effects of melatonin on spinal cord injury

Baran, Özlem; Çiçekçi, Esra; Dönder, Ahmet; Atiç, Ramazan; Deveci, Engin; Tuncer, Mehmet Cudi.

Int. j. morphol; 36 (2), 2018

Spinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury ...

Traumatismos de la Médula Espinal/tratamiento farmacológico, Melatonina/uso terapéutico, Traumatismos de la Médula Espinal/metabolismo, Melatonina/metabolismo, Inmunohistoquímica, Factor de Necrosis Tumoral alfa/metabolismo, Endotelina-1/metabolismo

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Expression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentas

Ekinci, Aysun; Aktas, Ayfer; Dönder, Ahmet; Ekinci, Cenap; Turgut, Abdulkadir; Deveci, Senay; Deveci, Engin.

Int. j. morphol; 36 (1), 2018

SUMMARY: Severe preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Sever...

Síndrome HELLP/patología, Síndrome HELLP/metabolismo, Endotelina-1/metabolismo, Antígeno Ki-67/metabolismo, Placenta/patología, Placenta/metabolismo, Preeclampsia/patología, Preeclampsia/metabolismo

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