Introdução: A aterosclerose é uma doença inflamatória crônica decorrente de alterações na parede das artérias de médio e grande calibre e associadas a diversos fatores de risco, dentre os quais destaca-se as hiperlipidemias, ou seja, o aumento plasmático das lipoproteínas, mas também outras ...
Inmunomodulación,
Aterosclerosis/patología,
Inmunización/instrumentación,
Anticuerpos Monoclonales/efectos adversos,
Arterias/anomalías,
Dieta/clasificación,
Células Productoras de Anticuerpos/clasificación,
Enfermedades Cardiovasculares/patología,
Factores de Riesgo,
Indolamina-Pirrol 2,3,-Dioxigenasa/administración & dosificación
The inverse relationship between HDL-C (high-density lipoprotein cholesterol) and cardiovascular disease is well established. However, it is consensus that the cholesterol content present in HDL does not capture its complexity, and other metrics need to be explored. HDL is a heterogeneous, protein-enrich...
Abstract Ligustrazine is widely used for the treatment of cardiovascular diseases in traditional Chinese medication. It has been reported that Ligustrazine decreases the concentration of intracellular calcium ions (Ca2+); however, the underlying mechanism remains unknown. In the present study, the effect...
The Gαq-RGS2 loop activator, 1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)-phenyl)-1H-1,2,4-triazol-5(4H)-one has demonstrated Gαq signaling inhibitor activity. Therefore, we aimed to study the effect of Gαq-RGS2 loop activator on isolated heart and aorta of normal rats. Heart and aorta were iso...
Abstract Glucosamine is known as anti-inflammatory, antioxidant and as neuroprotective as well as using to treat many of diseases. This work aimed to investigate the remedial effect of glucosamine (20mg/kg b.wt) against the damage induced by a single dose of γ-radiation (8Gy) or aluminium chloride (...
Enfermedades Cardiovasculares/etiología,
Exposición a la Radiación/efectos adversos,
Glucosamina/uso terapéutico,
Encefalopatías/etiología,
Cloruro de Aluminio/efectos adversos,
Encefalopatías/tratamiento farmacológico,
Enfermedades Cardiovasculares/tratamiento farmacológico,
Ratas Wistar,
Encefalopatías/patología,
Enfermedades Cardiovasculares/patología,
Reacción en Cadena de la Polimerasa,
Antiinflamatorios/uso terapéutico,
Modelos Animales de Enfermedad
Diabetes is an independent risk factor for the development of cardiovascular disease, with approximately 80% of cardiovascular mortality and morbidity linked to vascular complications such as atherosclerosis. It has been estimated that up to one-third of patients with diabetes mellitus use some form of c...
Abstract Objective: To evaluate the predictive value of epicardial fat thickness (EFT) in CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke or transient ischemic attack, vascular disease, age 65-74 years, sex category) score risk groups. Metho...
Tejido Adiposo/diagnóstico por imagen,
Tejido Adiposo/patología,
Factores de Edad,
Enfermedades Cardiovasculares/diagnóstico por imagen,
Enfermedades Cardiovasculares/etiología,
Enfermedades Cardiovasculares/patología,
Complicaciones de la Diabetes/diagnóstico,
Ecocardiografía/métodos,
Insuficiencia Cardíaca/complicaciones,
Insuficiencia Cardíaca/diagnóstico,
Hipertensión/complicaciones,
Hipertensión/diagnóstico,
Ataque Isquémico Transitorio/complicaciones,
Ataque Isquémico Transitorio/diagnóstico,
Modelos Logísticos,
Análisis Multivariante,
Pericardio/diagnóstico por imagen,
Pericardio/patología,
Estudios Prospectivos,
Factores de Riesgo,
Estadísticas no Paramétricas,
Accidente Cerebrovascular/complicaciones
As doenças cardiovasculares são a principal causa de morte no Brasil. Os fatores de risco modificáveis dessas doenças podem ser observados desde a infância e sua persistência está associada ao diagnóstico precoce de morbidades. Neste contexto, a adolescência é considerada um período chave para...
A doença cardiovascular (DCV) de origem aterosclerótica é a principal causa da morbidade
e mortalidade em pacientes com diabetes mellitus (DM). Tanto os fatores de risco cardiovascular
associados à resistência à insulina (RI) no contexto da síndrome da adiposidade visceral
(SAV) quanto a hiperglic...
Cardiovascular diseases are responsible for almost one third of all global deaths yearly, and therefore are largely studied. Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) have emerged as an exciting technology for cardiac disease modelling and personalised therapy. Neverthel...
