This study explored the alleviative effect of ginkgolide B on Parkinson's disease (PD) in rats. PD model was established in 20 rats, which were then randomly divided into model and treatment group, 10 rats in each group. Other 10 rats were selected as control group. The treatment group was treated wi...
Ginkgólidos/administración & dosificación,
Lactonas/administración & dosificación,
Modelos Animales de Enfermedad,
Fosfatidilinositol 3-Quinasas,
Fosfatidilinositoles,
Enfermedad de Parkinson/tratamiento farmacológico,
Estrés Oxidativo/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-akt,
Transducción de Señal,
Western Blotting,
Conducta Animal,
Inflamación
Diabetic neuropathy (DN) is a chronic diabetic complication, which is difficult to manage. The current investigation evaluates the effect of Nerium oleander (NO) in the management of diabetic neuropathy (DN). Diabetic neuropathy was induced by streptozotocin (STZ) [60 mg/kg, i.p.] and treated ...
Neuropatías Diabéticas/tratamiento farmacológico,
Mediadores de Inflamación,
Nerium/química,
Modelos Animales de Enfermedad,
Estrés Oxidativo/efectos de los fármacos,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Ratas Sprague-Dawley,
Peso Corporal/efectos de los fármacos,
Glucemia/efectos de los fármacos,
Motilidad Gastrointestinal/efectos de los fármacos,
Contracción Muscular/efectos de los fármacos
This study investigated Yishentongluo Recipe (YSTLF) effects on renal oxidative stress and fibrosis in membranous nephropathy (MN) rats. MN was induced by cationized bovine serum albumin injection. Rats were divided into control, MN, YSTLF, and benazepril groups. After ...
La alteración de la microbiota intestinal es uno de los factores claves
que afecta el inicio y la progresión de esteatosis hepática, al aumentar la permeabilidad intestinal e inducir un aumento circulante de la endotoxina lipopolisacárido
(LPS). El LPS puede llegar al hígado a través de la vena por...
Lipopolisacáridos/antagonistas & inhibidores,
Células Hep G2/efectos de los fármacos,
Aceites de Plantas/administración & dosificación,
Rosa,
Inflamación/prevención & control,
Estrés Oxidativo/efectos de los fármacos,
Supervivencia Celular,
Antioxidantes,
Antiinflamatorios,
Hígado Graso,
Citocinas
Oxidative stress (OS) occurs when the antioxidant defense system is overwhelmed by the predominance of reactive oxygen species (ROS) and pro-oxidant factors. Several diseases such as hypertension, insulin resistance, type 2 diabetes mellitus and neurodegenerative diseases are characterized by chronic OS....
Elkattawy, Hany A;
El-Sayed-Hassan, Ahmed;
Ebrahim-Alsemeh, Amira;
Abdelwahab, Ola A;
Eldesoqui, Mamdouh;
El-Sherbiny, Mohamed;
Ebrahim, Hasnaa Ali;
Nosseir, Nermine Samir;
Veeraraghavan, Vishnu Priya;
Ghazala, Mohamed;
Attia, Mohammed A;
Hadhoud, Shimaa.
SUMMARY: The main cause of mortality and disability globally is myocardial infarction (MI). Isoproterenol (ISO), a β-adrenoceptor agonist, has been used to induce rat myocardial necrosis. Whereas interleukin-37 (IL-37) has anti-inflammatory and cytoprotective properties. The study aimed to investiga...
The neuroprotective effect of flower and fruit parts of Capparis ovata Desf. var. palaestina Zoh. plant was investigated in H2O2-induced cytotoxicity in SH-SY5Y cells. The cells were treated with H2O2 alone or pretreated with flower (COMFL) and fruit extract (COMFR) of C. ovatavar. palaesti...
Capparis/química,
Extractos Vegetales/farmacología,
Extractos Vegetales/química,
Fármacos Neuroprotectores/farmacología,
Fármacos Neuroprotectores/química,
Peróxido de Hidrógeno/toxicidad,
Cromatografía Líquida con Espectrometría de Masas,
Espectrometría de Masas en Tándem,
Neuroblastoma,
Estrés Oxidativo/efectos de los fármacos,
Muerte Celular/efectos de los fármacos,
Ácidos Cafeicos/análisis,
Flavonoides/análisis,
Fenoles/análisis,
Ácidos Grasos Monoinsaturados/análisis,
Enfermedades Neurodegenerativas/prevención & control
The current study was conducted to determine the neuroprotective role and mechanism of action of Linalool (LIN) in SCI. The SCI in Sprague-Dawley (SD) rats was induced by weight-drop contusion model. Results of the suggested that LIN showed improvement in the locomo...
Monoterpenos Acíclicos/administración & dosificación,
Monoterpenos Acíclicos/farmacología,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Ratas Sprague-Dawley,
Estrés Oxidativo/efectos de los fármacos,
Inflamación,
Western Blotting,
FN-kappa B/antagonistas & inhibidores,
Receptor Toll-Like 4/antagonistas & inhibidores,
Transducción de Señal/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática
Bosanac, Milana;
Amidzic, Jelena;
Stefanovic, Maja;
Radic, Jelena;
Kolarov-Bjelobrk, Ivana;
Janicic, Stefan;
Gojkovic, Zdenka;
Lazic, Bojana;
Djokanovic, Dejan;
Misan, Aleksandra;
Cvetkovic, Biljana;
Stupar, Alena;
Martic, Nikola;
Andrejic-Visnjic, Bojana.
SUMMARY: Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study w...
Cardiotoxicidad/prevención & control,
Cucurbita/química,
Carotenoides/administración & dosificación,
Doxorrubicina/toxicidad,
Antibióticos Antineoplásicos/toxicidad,
Neoplasias/tratamiento farmacológico,
Peroxidación de Lípido,
Catalasa,
Glutatión Transferasa,
Glutatión Peroxidasa,
Ratas Wistar,
Antioxidantes,
Estrés Oxidativo/efectos de los fármacos,
Cardiotónicos
Hemodialysis, along with chronic kidney disease (CKD), intensifies the inflammatory process and oxidative stress in patients undergoing treatment. In this context, Vitamin E supplementation can mitigate the deleterious effects resulting from these processes. This is a systematic review whose objective wa...
