SUMMARY: Overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in various tumor tissues and cell lines was found to promote tumor cell proliferation, migration, and invasion. However, the role of MALAT1 in gastric cancer (GC) is still unclear. We aimed to investigate the corre...
Neoplasias Gástricas/patología,
ARN Largo no Codificante,
Proliferación Celular,
Factor A de Crecimiento Endotelial Vascular,
Serina-Treonina Quinasas TOR,
Transducción de Señal,
Neoplasias Gástricas/genética,
ARN/genética,
Western Blotting,
Genes Reporteros,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación Neoplásica de la Expresión Génica,
Movimiento Celular,
Apoptosis
SUMMARY: Angiogenesis, a process by which new blood vessels are generated from pre-existing ones, is significantly compromised in tumor development, given that due to the nutritional need of tumor cells, pro-angiogenic signals will be generated to promote this process and thus receive the oxygen and nutr...
The mechanisms of action (MA) of electroconvulsive therapy (ECT) in affective disorders are poorly understood. We synthesized and discussed the evidence provided by primary studies and systematic reviews in humans. There are differences in the methylation of candidate genes involved in the response to EC...
SUMMARY: Neuropeptide calcitonin gene-related peptide (CGRP) is a neurotransmitter related to vasculogenesis during organ development. The vascular endothelial growth factor A (VEGF-A) is also required for vascular patterning during lung morphogenesis. CGRP is primarily found in organs and initially appe...
Abstract Vascular endothelial growth factor (VEGF) is an essential angiogenic factor in breast cancer development and metastasis. Small interfering RNAs (siRNAs) can specifically silence genes via the RNA interference pathway, therefore were investigated as cancer therapeutics. In this study, we investig...
Abstract Angiotensin II (AngII) causes endothelial dysfunction. Eucommia ulmoides extract (EUE) is documented to manipulate AngII, but its impact on cardiac microvascular endothelial cell (CMVEC) function remains unknown. This study determines the effects of EUE on AngII-treated CMVECs. CMVECs were trea...
SUMMARY: This study is to investigate the role and mechanism of RGD peptide in laryngeal cancer stem cells (CSCs). Laryngeal cancer CD133+Hep-2 CSCs were sorted by flow cytometry. RGD peptide was co-cultured with sorted laryngeal CSCs. Cell proliferation was detected with CCK-8 assay. The mRNA levels of ...
Oligopéptidos/metabolismo,
Integrina alfaVbeta3/antagonistas & inhibidores,
Neoplasias Laríngeas,
Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores,
Proliferación Celular,
Western Blotting,
Citometría de Flujo,
Inmunohistoquímica,
Factor A de Crecimiento Endotelial Vascular/genética,
ARN Mensajero/antagonistas & inhibidores,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Células Madre Neoplásicas,
Neovascularización Patológica,
Cartilla de ADN
CONTEXTO: Os PCDT são documentos que visam garantir o melhor cuidado de saúde diante do contexto brasileiro e dos recursos disponíveis no SUS. Podem ser utilizados como materiais educativos aos profissionais de saúde, auxílio administrativo aos gestores, regulamentação da conduta assistencial pera...
Degeneración Macular/diagnóstico,
Degeneración Macular/terapia,
Degeneración Macular/tratamiento farmacológico,
Microscopía con Lámpara de Hendidura/instrumentación,
Angiografía con Fluoresceína/instrumentación,
Coagulación con Láser/instrumentación,
Fotoquimioterapia/instrumentación,
Factor A de Crecimiento Endotelial Vascular/uso terapéutico,
Ranibizumab/uso terapéutico,
Bevacizumab/uso terapéutico,
Protocolos Clínicos,
Sistema Único de Salud,
Brasil
SUMMARY: Laser photobiomodulation (laser PBM) is known to be able to accelerate burn wound healing in the animal model; however little evidence exists on the action of laser PBM on the expression of important proteins in wound healing in the animal model, such as VEGF and TGF-ß1. The aim of this study w...
Purpose:
To evaluate the ameliorative effect of mesenchymal stem cells (MSCs) on acetic acid colitis model via Nrf2/HO-1 pathway in rats.
Methods:
In this study, 30 rats were divided into three groups. Acute colitis was induced by rectal administration of 4% solution of acetic acid. MSCs were injected i...
