Background and Objectives: Ideal dosage forms for pediatric use are liquid because this population has difficulty swallowing. However, the pharmaceutical market does not have a large arsenal. To solve this situation, it is necessary to adapt drugs intended for the adult public in the form of oral solutio...
Introducción: los medicamentos antitiroideos son una de las alternativas terapéuticas en el tratamiento de la enfermedad de Graves. Sin embargo, pueden generar efectos adversos severos poco frecuentes en el plano hematológico, como la anemia aplásica, la cual se ha asociado con altas dosis de estos m...
O organogel é formado por uma matriz tridimensional composta de filamentos que se auto-organizam em uma rede entrelaçada e que, por seu tipo de estrutura, pode ser utilizado com o objetivo de atuar como um implante que se forma in situ, sendo capaz de se comportar como uma forma farmacêutica de libera...
Disolución,
Poloxámero/análisis,
Lecitinas/análisis,
Meloxicam/antagonistas & inhibidores,
Drogas Veterinarias/análisis,
Cromatografía Liquida/métodos,
Cromatografía Líquida de Alta Presión/métodos,
Farmacéuticos/clasificación,
Formas de Dosificación,
Veterinarios,
Métodos,
Preparaciones Farmacéuticas/análisis,
Química Farmacéutica/instrumentación
Abstract A stability indicating UPLC method has been developed and validated for the simultaneous determination of fosnetupitant and palonosetron in bulk and in injection dosage form. This combination is used for the prevention of acute and delayed nausea and vomiting associated with initial and repeated...
Abstract A simple, precise, accurate and robust high performance liquid chromatographic method has been developed for simultaneous estimation of Torsemide and Eplerenone in tablet dosage form. Design of experiment was applied for multivariate optimization of the experimental conditions of RP-HPLC method....
Abstract Simple, precise, accurate and specific spectrophotometric methods are progressed and validated for concurrent analysis of Furosemide (FUR) and Spironolactone (SPR) in their combined dosage form depend on spectral analysis procedures. Furosemide (FUR) in the binary mixture could be analyzed at i...
Chemotherapy induced nausea and vomiting (CINV) and post-operative nausea and vomiting (PONV) is a problem, often occurs in patient. Inspite of high bioavailability, the demerits such as: hepatic first pass metabolism and invasive nature of oral and parenteral dosage forms can be avoided with anti-emetic...
Plastificantes/efectos adversos,
Solubilidad,
Películas Cinematográficas/clasificación,
Formas de Dosificación,
Métodos,
Náusea y Vómito Posoperatorios,
Ondansetrón/antagonistas & inhibidores,
Pacientes/clasificación,
Preparaciones Farmacéuticas/análisis,
Quimioterapia/instrumentación,
Vómitos
Tizanidine hydrochloride is a centrally acting skeletal muscle relaxant, used in the management of spasticity. This drug is commercially available only as tablets, which highlights the need to develop oral liquid formulations. In the hospital environment, this aspect is circumvented by the preparation of...
The aim of this work was to perform solubility studies for fexofenadine hydrochloride and establish dissolution conditions for this drug in oral suspension dosage form. The solubility study was executed through the shake-flask method, below 37 ºC±1 ºC, at 100 rpm stirring for 12 h in three buffer solu...
A simple, sensitive, precise, accurate and robust high performance liquid chromatographic method has been developed for simultaneous estimation of saxagliptin (SAXA) and dapagliflozin (DAPA) in pharmaceutical formulation. Design of experiments (DoE) was applied for multivariate optimization of the experi...
