This study explored the alleviative effect of ginkgolide B on Parkinson's disease (PD) in rats. PD model was established in 20 rats, which were then randomly divided into model and treatment group, 10 rats in each group. Other 10 rats were selected as control group. The treatment group was treated wi...
Ginkgólidos/administración & dosificación,
Lactonas/administración & dosificación,
Modelos Animales de Enfermedad,
Fosfatidilinositol 3-Quinasas,
Fosfatidilinositoles,
Enfermedad de Parkinson/tratamiento farmacológico,
Estrés Oxidativo/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-akt,
Transducción de Señal,
Western Blotting,
Conducta Animal,
Inflamación
SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active...
Cicatrización de Heridas/efectos de los fármacos,
Quemaduras/tratamiento farmacológico,
Piel,
Modelos Animales de Enfermedad,
Técnicas In Vitro,
Fibroblastos,
Fosfatidilinositol 3-Quinasas,
Proteínas Proto-Oncogénicas c-akt,
Naftoquinonas/administración & dosificación,
Ratones Endogámicos C57BL,
Naftoquinonas/farmacología,
Proliferación Celular/efectos de los fármacos
BACKGROUND/AIMS: Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular protection and ischemic tissue ...
Abstract Objective Oral squamous cell carcinoma (OSCC) is one of the common type of cancer that leads to death; and is becoming a global concern. Due to the lack of efficient chemotherapeutic agents for patients with oral cancer, the prognosis remains poor. 6-shogaol, a bioactive compound of ginger, ha...
Epidermal growth factor receptor (EGFR) signaling and components of the fibrinolytic system, including urokinase-type plasminogen activator (uPA) and thrombomodulin (TM), have been implicated in tumor progression. In the present study, we employed cBioPortal platform (http://www.cbioportal.org/), cancer ...
Platycodin D (PD) is a major constituent of Platycodon grandiflorum and has multiple functions in disease control. This study focused on the function of PD in bladder cancer cell behaviors and the molecules involved. First, we administered PD to the bladder cancer cell lines T24 and 5637 and the human ur...
Apoptosis,
Línea Celular Tumoral,
Proliferación Celular,
Regulación Neoplásica de la Expresión Génica,
MicroARNs,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Saponinas,
Triterpenos,
Neoplasias de la Vejiga Urinaria/tratamiento farmacológico,
Neoplasias de la Vejiga Urinaria/genética
Altered expression of miR-182 has been observed in various types of human cancer. The purpose of this study was to investigate the expression of miR-182 and its role in prostate cancer (PCa). Expression of miR-182 and ST6GALNAC5 in tumor tissues and the Du145 PCa cell line was analyzed. Cell proliferatio...
Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism of sorafenib resistance remains unclear. Several microRNAs (miRNAs) have been identified as playing a role in impairing the sensitivity of tumor cells to treatment. We ...
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Línea Celular Tumoral,
Proliferación Celular,
Resistencia a Antineoplásicos,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
MicroARNs/genética,
Fosfohidrolasa PTEN/genética,
Fosfatidilinositol 3-Quinasas/metabolismo,
Transducción de Señal,
Sorafenib/farmacología,
Serina-Treonina Quinasas TOR
OBJECTIVE: The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: KCNQ1OT1 expression was detected in ESCC tissues ...
SUMMARY OBJECTIVE In this study, we aimed to investigate the role of COL6A3 on cell motility and the PI3K/AKT signaling pathway in osteosarcoma. METHODS The relative expression of COL6A3 was achieved from a GEO dataset in osteosarcoma tissue. siRNA technology was applied to decrease the COL6A3 expres...
