BACKGROUND: Ototoxicity is a side effect of drugs and medications that usually leads to bilateral and symmetric sensorineural hearing loss that commonly affects the high-frequency range initially, with or preceded by tinnitus. Possible ototoxic side effects of calcineurin inhibitor immunosuppressants hav...
Audiometría de Tonos Puros,
Inhibidores de la Calcineurina/efectos adversos,
Estudios de Seguimiento,
Pérdida Auditiva Sensorineural/inducido químicamente,
Inmunosupresores/efectos adversos,
Trasplante de Riñón,
Trasplante de Hígado,
Ototoxicidad,
Estudios Prospectivos,
Tacrolimus/efectos adversos,
Factores de Tiempo
O desenvolvimento da síndrome metabólica após o transplante renal (TxR) é evidenciado na literatura e se caracteriza por alterações que conferem a redução da função do enxerto. Objetivo: O objetivo deste trabalho é descrever a prevalência da síndrome metabólica e identificar variáveis que ...
No período de pós Transplante Renal (TxR) o uso de imunossupressores é indicado. Seu uso crônico se associa a alterações endocrinometabólicas e do estado nutricional. Objetivo: Avaliar o estado nutricional de pacientes com Doenças Renais Crônicas (DRC) submetidos ao transplante renal. Método: T...
Introduction: Immunosuppressants (ISS) are the most crucial tools used in the therapeutic regimens of transplant recipients. Nevertheless, these drugs are not the only ones adopted by patients; therefore, knowing the possible drug-drug interactions (DDIs) between immunosuppressants and other drugs common...
BACKGROUND: Mycophenolate mofetil (MMF) is a largely used immunosuppressive agent in the prevention of transplant rejection and lupus nephritis. Its use has been extended to other immune-mediated diseases (ID). AIM: To assess the off-label use of MMF, its performance as a glucocorticoid sparing agent, th...
Abrantes, Fabiano Ferreira;
Moraes, Marianna Pinheiro Moraes de;
Albuquerque Filho, José Marcos Vieira de;
Alencar, Jéssica Monique Dias;
Lopes, Alexandre Bussinger;
Pinto, Wladimir Bocca Vieira de Rezende;
Souza, Paulo Victor Sgobbi de;
Oliveira, Enedina Maria Lobato de;
Oliveira, Acary de Souza Bulle de;
Pedroso, José Luiz;
Barsottini, Orlando Graziani Povoas.
ABSTRACT For patients with autoimmune diseases, the risks and benefits of immunosuppressive or immunomodulatory treatment are a matter of continual concern. Knowledge of the follow-up routine for each drug is crucial, in order to attain better outcomes and avoid new disease activity or occurrence of adve...
La terapia con fármacos antagonistas del factor de necrosis tumoral alfa ha sido beneficiosa en el tratamiento de varias enfermedades como las del tejido conectivo e inflamatorias del intestino, pero no está exenta de riesgos. Las principales complicaciones de estas drogas inmunosupresoras son las infe...
ABSTRACT BACKGROUND: The use of immunosuppressive drugs after liver transplantation (LT) is associated with the development of systemic arterial hypertension (SAH), in addition to other comorbidities of metabolic syndrome. OBJECTIVE: Therefore, the purpose of this study was to analyze the time after ...
Tustumi, Francisco;
Miranda Neto, Antonio Afonso de;
Silveira Júnior, Sérgio;
Fernandes, Felipe Alexandre;
Silva, Miller Barreto de Brito e;
Ernani, Lucas;
Nacif, Lucas Souto;
Coelho, Fabricio Ferreira;
Andraus, Wellington;
Bernardo, Wanderley Marques;
Herman, Paulo;
Carneiro-DAlbuquerque, Luiz Augusto.
A combination of immunosuppressants may improve outcomes due to the synergistic effect of their different action mechanisms. Currently, there is no consensus regarding the best immunosuppressive protocol after liver transplantation. This review aimed to evaluate the effectiveness and safety of tacrolimus...
Al igual que en las enfermedades autoinmunes y reumáticas, las infecciones por virus pueden ser disparadores de mecanismos inmunopatogénicos. El SARSCoV-2 puede causar la liberación de citocinas y provocar un daño tisular grave, sobre todo pulmonar, con peligro para la vida. Se suma a ello el riesgo ...
