Results: 35

A rat model of rheumatoid arthritis: TDZD-8 is associated with the protection against the induction of the synovium knee joint IL-17A/GSK3beta/ROS/alpha-SMA axis of fibrosis

Int. j. morphol; 41 (2), 2023
SUMMARY: Rheumatoid arthritis (RA) that affects the synovial knee joint causes swelling of the synovial membrane and tissue damage. Interleukin-17A (IL-17A) and the enzyme glycogen synthase kinase-3β (GSK3β) are involved in the pathogenesis of RA. The link between IL-17A, GSK3β, the oxidat...

TNF-alpha and IL-17 cytokine levels in Brazilian patients with ankylosing spondylitis after anti-TNF therapy

Abstract The aim of this study was to evaluate tumor necrosis factor alpha (TNF-α), interleukin (IL)- 17A/F levels in the serum of ankylosing spondylitis (AS) patients after anti-TNF therapy, in order to understand how these cytokines are involved in this therapeutic response. Forty-four AS patients wer...

Research on Molecular Mechanism of Fructus Ligustri Lucidi against Osteoporosis based on Network Pharmacology

Abstract TCMSP platform of systematic pharmacology of traditional Chinese medicine This study aimed to investigate the molecular mechanism of Fructus Ligustri Lucidi (NZZ, Chinese abbreviation) against osteoporosis (OP) by means of network pharmacology.ChemDraw Professional 15.1 software and Molinspirati...

IL-17 E SUA RELAÇÃO COM AS LESÕES PERIRRADICULARES: REVISÃO DE LITERATURA
IL-17 AND ITS RELATIONSHIP TO PERIRRADICULAR INJURIES: LITERATURE REVIEW

Rev. Rede cuid. saúde; 15 (2), 2021
A lesão perirradicular consiste em uma doença inflamatória de origem microbiana causada pelo desenvolvimento da infecção no sistema de canais radiculares. Citocinas pró-inflamatórias e imunoregulatórias são fundamentais para o desenvolvimento dessas lesões. No entanto, pouco se sabe sobre com...

Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata

An. bras. dermatol; 96 (5), 2021
Abstract Background: Alopecia areata (AA) is a hair disease that causes hair loss without scarring. The etiopathogenesis of AA has not been fully understood yet. Objective: To determine serum interleukin levels (IL-2, IL-4, IL-15, and IL-17) in patients diagnosed with alopecia areata and to investigate...

Fibrosis pulmonar inducida por metotrexato en un paciente con psoriasis

Dermatol. argent; 27 (2), 2021
La fibrosis pulmonar a causa del metotrexato es un efecto adverso infrecuente, observado principalmente en los pacientes con artritis reumatoide, aunque también se vio, de manera escasa, en el tratamiento de la psoriasis. Se presenta el caso de un paciente con psoriasis que desarrolló fibros...

Immunological Characteristics between αß TDC and γδ TDC Cells in the Spleen of Breast Cancer-Induced Mice

Abstract Objective To evaluate the antitumoral role of γδ TDC cells and αβ TDC cells in an experimental model of breast cancer. Methods Thirty female Balb/c mice were divided into 2 groups: control group (n=15) and induced-4T1 group (n=15), in which the mice received 2 x 105 4T1 m...

Papel de la interleuquina-17 en procesos inflamatorios y patologías pulmonares

Med. UIS; 34 (1), 2021
Resumen Introducción: Cuatro de las diez principales causas de muerte en el mundo corresponden a patologías pulmonares donde las infecciones respiratorias se ubican en tercer lugar y a su vez son uno de los principales motivos de consulta médica. Por otro lado, la interleuquina IL-17 parece tener un ...

Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis,

An. bras. dermatol; 96 (2), 2021
Abstract Background: Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid has been poorly evaluated. Objective: To evaluate the levels of IL-17A, IL-22, IL-23, S100A7, ...

Estudio de mecanismos efectores y contra-reguladores mediados por la sobre-activación de inflamasoma durante la respuesta anti-tumoral

La manipulación del sistema inmune utilizando inmunoterapias para desencadenar respuestas anti-tumorales ha revolucionado el tratamiento de una variedad de cánceres, sin embargo, pocos pacientes se benefician de las terapias desarrolladas hasta el momento. Por este motivo, es necesario identificar nuev...