Abstract Focal Adhesion Kinase (FAK) protein participates in proliferation, migration, cell survival, and apoptosis process. It has been described as overexpressed in several neoplasms being a promising target for therapy. BCR-ABL negative chronic Myeloproliferative Neoplasms (MPN) are clonal disorders c...
Abstract Vein thrombosis of unusual sites such as the splanchnic region continues to be not only a diagnostic but also a therapeutic challenge for the clinician due to its manifestation and associated pathologies. Latent JAK2 (Janus kinase 2) positive myeloproliferative neoplasm associated with sticky pl...
ABSTRACT Background: In Philadelphia chromosome-negative myeloproliferative neoplasm (MPN) models, reactive oxygen species (ROS) are elevated and have been implicated in genomic instability, JAK2/STAT signaling amplification, and disease progression. Although the potential effects of ROS on the MPN phen...
Valladares, Ximena;
Benavente, Rafael;
Rojas, Christine;
Peña, Camila;
Valenzuela, Rodrigo;
Monardes, Virginia;
López, Hernán;
Abarca, Marcelo;
León, Pilar;
Osorio, Rocío;
Pérez, Erika;
Soto, Pablo;
Rocca, Gabriel La;
Cardemil, Daniela;
Torres, Vivianne;
Intriago, Marvila;
Cabrera, María Elena;
Undurraga, María Soledad.
BACKGROUND: Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF). ...
Chile/epidemiología,
Janus Quinasa 2/genética,
Mutación,
Trastornos Mieloproliferativos/diagnóstico,
Trastornos Mieloproliferativos/epidemiología,
Trastornos Mieloproliferativos/genética,
Policitemia Vera/diagnóstico,
Policitemia Vera/epidemiología,
Policitemia Vera/genética,
Mielofibrosis Primaria/diagnóstico,
Mielofibrosis Primaria/epidemiología,
Mielofibrosis Primaria/genética,
Trombocitemia Esencial/diagnóstico,
Trombocitemia Esencial/genética
CONTEXTO CLÍNICO: La enfermedad por el Coronavirus 2019 (COVID–19, por su sigla en inglés Coronavirus Disease 2019) es una enfermedad respiratoria de humanos producida por un nuevo coronavirus identificado con la sigla SARS-CoV-2. El 11 de marzo de 2020 la Organización Mundial de la Salud (OMS) decl...
OBJECTIVES: TTP488, an antagonist of the receptor for advanced glycation end-products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). However, the mechanism underlying the protective action of TTP488 against AD has not yet been fully explored. METHODS...
Abstract Background and objective: in the global scientific literature, the frequency of JAK2 is highly heterogenous in chronic myeloproliferative neoplasms. The objective of this study was to analyze the prevalence of the JAK2 mutation in primary myelofibrosis (PMF) and compare it according to the dete...
BACKGROUND:
The present study analyzed the synergistic protective effect of β-alanine and taurine against myocardial ischemia/reperfusion. Myocardial infarct size, lipid peroxidation, and levels of glutathione peroxidase (Gpx), superoxide dismutase (SOD), reduced glutathione (GSH), catalase, tumor necro...
Taurina/uso terapéutico,
beta-Alanina/uso terapéutico,
Cardiotónicos/uso terapéutico,
Isquemia Miocárdica/tratamiento farmacológico,
Daño por Reperfusión/tratamiento farmacológico,
Cardiopatías/tratamiento farmacológico,
Peroxidación de Lípido,
Especies Reactivas de Oxígeno,
Ratas Wistar,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Simulación del Acoplamiento Molecular,
Inflamación,
Glutatión Peroxidasa,
Janus Quinasa 2,
Superóxido Dismutasa
Trombose essencial é uma das doenças mieloproliferativas crônicas, rara e de etiologia ainda desconhecida, mas que apresenta risco alto de eventos trombóticos e/ou hemorrágicos, uma vez que acomete as células megacariocíticas e, consequentemente, as plaquetas. O objetivo deste trabalho foi realiza...
SUMMARY The essential thrombocythemia is one of the seven described forms of myeloproliferative neoplasms. It is characterized by megakaryocytic hyperplasia with consequent thrombocytosis maintained in the peripheral blood, favoring the occurrence of thrombo-hemorrhagic phenomena. We present the case of ...
