Medicinal plants are used to cure diseases, and their replacement
is frequent and affects public
health. The genus
Baccharis
has representatives within the medicinal flora of Argentina, although the
replacement of the species of this genus known under the vulgar name of "carqueja" by
Bacc...
Baccharis/química,
Antivirales/administración & dosificación,
Hepatitis B/tratamiento farmacológico,
Hojas de la Planta,
Línea Celular/efectos de los fármacos,
Antivirales/farmacología,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Replicación Viral/efectos de los fármacos,
Virus de la Hepatitis B/efectos de los fármacos,
Medicina Tradicional,
Asteraceae
Abstract Mammals have a limited capacity to regenerate their tissues and organs. One of the mechanisms associated with natural regeneration is dedifferentiation. Several small molecules such as vitamin C and growth factors could improve reprogramming efficiency. In this study, the NTERA2-D1 (NT2) cells w...
Abstract Glioblastoma multiforme is a tumor of the central nervous system. Focal Adhesion Kinase (FAK) and αB-crystalline are two proteins involved in glioblastoma development. In this study, we investigated whether the FAK/αB-crystalline interaction is important for glioblastoma cells, we aimed to inv...
O fenômeno conhecido como multidrug resistance (MDR) observado no câncer é
um grande desafio na busca por terapias mais eficientes. Esse fenótipo é o resultado da
combinação de vários fatores, como a alta expressão de bombas de efluxo da superfamília
de proteínas transportadoras ABC, que imped...
Introducción: Los bioderivados propuestos como candidatos a ingredientes alimentarios suelen requerir ciertas evaluaciones para las aplicaciones inmunonutricionales Los hongos comestibles-medicinales son un surtidor de compuestos con estas potencialidades. Entre ellos, las setas Pleurotus ostreatus cont...
Limanaqi, Fiona;
Zecchini, Silvia;
Saulle, Irma;
Strizzi, Sergio;
Vanetti, Claudia;
Garziano, Micaela;
Cappelletti, Gioia;
Parolin, Debora;
Caccia, Sonia;
Trabattoni, Daria;
Fenizia, Claudio;
Clerici, Mario;
Biasin, Mara.
BACKGROUND: Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxicity and the development and/or exacerbation of neuropathological manifestations, i...
Abstract Focal Adhesion Kinase (FAK) protein participates in proliferation, migration, cell survival, and apoptosis process. It has been described as overexpressed in several neoplasms being a promising target for therapy. BCR-ABL negative chronic Myeloproliferative Neoplasms (MPN) are clonal disorders c...
BACKGROUND: Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be discovered. METHODS: To explore the regulatory mechanisms of human SSCs, we analyzed pub...
Modelos celulares são muito utilizados na pesquisa experimental e, idealmente, constituem o primeiro nível de modelo de estudo. A utilização de modelos celulares permite, por exemplo, a primeira avaliação de tolerabilidade e de segurança de fármacos e tratamentos experimentais, além de permitir ...
Colorectal cancer is the 4thcause of cancer death; with considering the growth process of this cancer and the necessity of early diagnosis, the purpose of the research is to state the LncRNA 00970, LncRNA UCAI,and the Wntgene before and after the treatment by 5-Azacytidine epigenetic medi...
Técnicas In Vitro/métodos,
Azacitidina/análisis,
Biomarcadores,
ADN/análisis,
Diagnóstico Precoz,
Neoplasias Colorrectales/tratamiento farmacológico,
ARN Largo no Codificante/efectos de los fármacos,
Genes,
Epigenómica,
Línea Celular/efectos de los fármacos,
Neoplasias del Colon/diagnóstico,
Azacitidina/antagonistas & inhibidores,
Neoplasias Colorrectales/mortalidad,
Neoplasias Colorrectales/terapia,
ARN Largo no Codificante,
Neoplasias del Colon/tratamiento farmacológico,
Neoplasias del Colon/terapia
